Glycemic variability remains frequent in patients with type 1 diabetes treated with insulin
pumps. Heterogeneous spreads of insulin infused by pump in the subcutaneous (SC) tissue …

Aim To determine the effect of insulin on the resistance of subcutaneous tissue to the flow of
infusion fluids. Materials and methods Thirty subjects with type 1 diabetes wore two Accu …

Background: To deliver exact volumes of liquid subcutaneously (eg, during continuous
subcutaneous insulin infusion [CSII]), the insulin pump has to overcome not only frictional …

Background: This study assessed subcutaneous absorption kinetics of rapid-acting insulin
administered as a bolus using bolus delivery speeds commonly employed in commercially …

Background: The size and geometry of an insulin depot that is formed during subcutaneous
administration by an insulin pump is evaluated. A novel method is used to visualize …

Closed-loop insulin delivery in individuals with diabetes can potentially lead to near-normal
glucose profiles. To this end, existing subcutaneous glucose sensors and external insulin …

Background: The objective was to quantify hydrostatic effects on continuous subcutaneous
insulin infusion (CSII) pumps during basal and bolus insulin delivery. Methods: We tested …

Objective: Subcutaneous (sc) administration of fast-acting insulin analogues is the key in
conventional therapy of type 1 diabetes (T1D). A model of sc insulin absorption would be …

In this study we estimate the subcutaneous tissue counter pressure during drug infusion
from a series of injections of insulin in type 2 diabetic patients using a non-invasive method …

Background: Insulin pumps are used for basal rate and bolus insulin delivery in patients with
diabetes. In this in vitro study, accuracy of delivery of different commercial insulin pumps was …