An inverse U-shaped curve of resting-state networks in individuals at high risk of Alzheimer's disease

Q Ye, H Chen, F Su, H Shu, L Gong, C Xie… - The Journal of clinical …, 2018 - psychiatrist.com
Objective: Higher functional connectivity (FC) in resting-state networks has been shown in
individuals at risk of Alzheimer's disease (AD) by many studies. However, the longitudinal …

Apolipoprotein E ε4 specifically modulates the hippocampus functional connectivity network in patients with amnestic mild cognitive impairment

L Zhu, H Shu, D Liu, Q Guo, Z Wang… - Frontiers in aging …, 2018 - frontiersin.org
The presence of both apolipoprotein E (APOE) ε4 allele and amnestic mild cognitive
impairment (aMCI) are considered to be risk factors for Alzheimer's disease (AD). Numerous …

[HTML][HTML] Associations between Education Years and Resting-state Functional Connectivity Modulated by APOE ε4 Carrier Status in Cognitively Normal Older Adults

J Kim, S Kim, YH Um, SM Wang, REY Kim… - Clinical …, 2024 - ncbi.nlm.nih.gov
Objective Cognitive reserve has emerged as a concept to explain the variable expression of
clinical symptoms in the pathology of Alzheimer's disease (AD). The association between …

Dynamics of the brain functional network associated with subjective cognitive decline and its relationship to apolipoprotein E€ 4 alleles

B Zhou, X Wu, L Tang, C Li - Frontiers in Aging Neuroscience, 2022 - frontiersin.org
The aim of our study was to explore the dynamic functional alterations in the brain in patients
with subjective cognitive decline (SCD) and their relationship to apolipoprotein E (APOE)€ 4 …

Aberrant interhemispheric functional connectivity within default mode network and its relationships with neurocognitive features in cognitively normal APOE ε 4 elderly …

H Lu, SL Ma, SWH Wong, CWC Tam… - International …, 2017 - cambridge.org
Background: Default mode network (DMN) is vulnerable to the effects of APOE genotype.
Given the reduced brain volumes and APOE ε 4-related brain changes in elderly carriers, it …

Resting-state functional connectivity disruption as a pathological biomarker in autosomal dominant Alzheimer disease

RX Smith, JF Strain, A Tanenbaum, AM Fagan… - Brain …, 2021 - liebertpub.com
Aim: Identify a global resting-state functional connectivity (gFC) signature in mutation
carriers (MC) from the Dominantly Inherited Alzheimer Network (DIAN). Assess the gFC with …

Comparison of ApoE-related brain connectivity differences in early MCI and normal aging populations: an fMRI study

F McKenna, BB Koo, R Killiany… - Brain imaging and …, 2016 - Springer
In this study, we used resting-state functional magnetic resonance imaging (rs-fMRI) scans
from subjects with early mild cognitive impairment (EMCI) and control subjects to study …

Resting state functional connectivity signature differentiates cognitively normal from individuals who convert to symptomatic Alzheimer's disease

JK Wisch, CM Roe, GM Babulal… - Journal of …, 2020 - content.iospress.com
Background: Changes in resting state functional connectivity (rs-fc) occur in Alzheimer's
disease (AD), but few longitudinal rs-fc studies have been performed. Most studies focus on …

Resting-state brain connectivity in healthy young and middle-aged adults at risk of progressive Alzheimer's disease

L Kucikova, J Goerdten, ME Dounavi, E Mak… - Neuroscience & …, 2021 - Elsevier
Functional brain connectivity of the resting-state networks has gained recent attention as a
possible biomarker of Alzheimer's Disease (AD). In this paper, we review the literature of …

[HTML][HTML] The link between static and dynamic brain functional network connectivity and genetic risk of Alzheimer's disease

MSE Sendi, E Zendehrouh, CA Ellis, Z Fu, J Chen… - NeuroImage: Clinical, 2023 - Elsevier
Apolipoprotein E (APOE) polymorphic alleles are genetic factors associated with Alzheimer's
disease (AD) risk. Although previous studies have explored the link between AD genetic risk …