Aims Type 1 diabetes, as a kind of autoimmune diseases, usually results from the broken-
down of self-tolerance. Autoimmune regulator (Aire), as a transcription factor, induces …

Autoimmune regulator (Aire) can promote the ectopic expression of peripheral tissue-
restricted antigens (TRAs) in thymic medullary epithelial cells (mTECs), which leads to the …

Aire plays an important role in central immune tolerance by regulating the transcription of
thousands of genes. However, the role of Aire in the peripheral immune system is poorly …

Autoimmune regulator (Aire) plays an indispensable role in maintaining central immune
tolerance by promoting the ectopic expression of tissue-restricted antigens (TRAs) in …

The autoimmune regulator (Aire) protein is a transcriptional activator that is essential in
central immune tolerance, as it regulates the ectopic expression of many tissue‑restricted …

Autoimmune regulator (Aire) is one of the most crucial genes expressed in the thymus,
where it orchestrates the promiscuous expression and presentation of tissue-specific …

Tolerogenic dendritic cells (tolDCs) may offer an interesting intervention strategy to re-
establish Ag-specific tolerance in autoimmune diseases, including type 1 diabetes (T1D) …

The strong genetic association between autoimmune regulator (AIRE) and autoimmune
diseases indicates its critical role in immune tolerance. AIRE deficiency is thought to …

Tolerogenic dendritic cells (TolDCs) are attractive therapeutic options for autoimmune
disorders because they suppress autologous T-cell responses. Dendritic cells (DCs) are …

Activation of autoreactive T cells can lead to autoimmune diseases such as insulin-
dependent diabetes mellitus (IDDM). The initiation and maintenance of IDDM by dendritic …