Chronic stress is one of the most relevant triggering factors for major depression. Microglial
cells are highly sensitive to stress and, more generally, to environmental challenges …

Background Interactions between fractalkine (CX 3 CL1) and fractalkine receptor (CX 3
CR1) regulate microglial activation in the CNS. Recent findings indicate that age-associated …

Clinical studies suggest that key genetic factors involved in stress resilience are related to
the innate immune system. In the brain, this system includes microglia cells, which play a …

Neural circuits are constantly monitored and supported by the surrounding microglial cells,
using finely tuned mechanisms which include both direct contact and release of soluble …

Multiple sclerosis (MS), an inflammatory demyelinating disease of the central nervous
system (CNS) is the leading cause of non-traumatic neurological disability in young adults …

Abstract Background Fractalkine (CX3CL1; FKN) is a chemokine expressed by neurons that
mediates communication between neurons and microglia. By regulating microglial activity …

Microglial cells participate in brain development and influence neuronal loss and synaptic
maturation. Fractalkine is an important neuronal chemokine whose expression increases …

Fractalkine (CX3CL1) to fractalkine receptor (CX3CR1) interactions in the brain are involved
in the modulation of microglial activation. Our recent findings indicate that there is microglial …

Microglia, the resident inflammatory cells of the CNS, are the only CNS cells that express the
fractalkine receptor (CX3CR1). Using three different in vivo models, we show that CX3CR1 …

In the CNS, the chemokine CX3CL1 (fractalkine) is expressed on neurons while its specific
receptor CX3CR1 is expressed on microglia and macrophages. Microglia play an important …