Microglia are immune cells that play a crucial role in maintaining brain homeostasis. Among
the mechanisms of communication between microglia and neurons, the CX3CL1/CX3CR1 …

Background Production of inflammatory mediators by reactive microglial cells in the brain is
generally considered the primary mechanism underlying the development of symptoms of …

Homo and heterozygote cx3cr1 mutant mice, which harbor a green fluorescent protein
(EGFP) in their cx3cr1 loci, represent a widely used animal model to study microglia and …

Chemokines are important modulators of neuroinflammation and neurodegeneration. In the
brains of Alzheimer's disease (AD) patients and in AD animal models, the chemokine …

A recently identified chemokine, fractalkine, is a member of the chemokine gene family,
which consists principally of secreted, proinflammatory molecules. Fractalkine is …

Chronic pain represents a major problem in clinical medicine. Whilst the acute pain that is
associated with tissue injury is a protective signal that serves to maintain homeostasis …

Immunosenescence, or ageing of the immune system, contributes to the increased morbidity
and mortality seen in the elderly population. Premature immunosenescence is shown to …

Abstract Chemokine (C-X3-C motif) ligand 1 (CX 3 CL1, also known as fractalkine) and its
receptor chemokine (C-X3-C motif) receptor 1 (CX 3 CR1) are widely expressed in immune …

Abstract CX3CL1 (fractalkine) is the only member of the CX3C (delta) subfamily of
chemokines which is unique and combines the properties of both chemoattractant and …

Functional expression of CX3CR1, a recently discovered receptor for the chemokine
fractalkine, was investigated in cultured rat microglia. Reverse transcriptase polymerase …