Fractalkine is a chemokine widely and constitutively expressed in the brain and, as
suggested by in vitro studies, it is involved in brain inflammatory responses. In this study, we …

Microglial cells are the resident immune cells of the central nervous system. They are
essential for normal functioning, maintenance of tissue integrity, clearance of dying neurons …

Fractalkine (FKN), also known as neurotactin, is a CX3C chemokine that exists in both
secreted and neuronal membrane-bound forms and is upregulated during brain …

Fractalkine, a chemokine binding to only one known receptor CX3CR1, has recently been
proposed to be a neuron-to-glia signal in the spinal cord leading to microglial activation and …

Alzheimer's disease is characterized by amyloid plaques, neurofibrillary tangles, glial
activation, and neurodegeneration. In mouse models, inflammatory activation of microglia …

Background Inflammation is a common pathophysiological trait found in both hypertension
and cardiac vascular disease. Recent evidence indicates that fractalkine (FKN) and its …

Fractalkine is a recently identified chemokine that exhibits cell adhesion and
chemoattractive properties. It represents a unique member of the chemokine superfamily …

The concept of diabetic retinopathy (DR) has been extended from microvascular disease to
neurovascular disease in which microglia activation plays a remarkable role. Fractalkine …

Fractalkine is a CX3C chemonkine that appears to be a neuron-to-microglia signal molecule
in the central nervous system. We studied the expression of fractalkine in normal human …

Our purpose was to investigate in human neurons the neuroprotective pathways induced by
Fractalkine (FKN) against glutamate receptor‐induced excitotoxicity. CX3CR1 and FKN are …