B cell development is a multistep process that is tightly regulated at the transcriptional level.
In recent years, investigators have shed light on the transcription factor networks involved in …

The generation of B cells is the result of several cell lineage choices, cell commitment and
differentiation. These cellular transitions take place in a stepwise manner and are regulated …

The progression of hematopoietic stem cells (HSCs) to the B lymphocyte lineage requires
that uncommitted progenitors successfully negotiate the transition from multipotency to …

Powerful techniques—including gene targeting, genomic and proteomic analyses—are
allowing a more complete understanding of the transcription factors that drive B-cell …

B lymphocyte development is dependent on the interplay between the chromatin landscape
and lineage-specific transcription factors. It has been suggested that B lineage commitment …

The generation, development, maturation and selection of mammalian B lymphocytes is a
complex process that is initiated in the embryo and proceeds throughout life to provide the …

The B cell developmental pathway represents a leading system for the analysis of regulatory
circuits that orchestrate cell fate specification, commitment, and differentiation. We review the …

B-cell fate determination requires the action of transcription factors that operate in a
regulatory network to activate B-lineage genes and repress lineage-inappropriate genes …

The generation of B lymphocytes from hematopoietic progenitors requires lineage-specific
transcription factors that progressively direct cell fate choices. Differentiation of …

B lymphoid development is initiated by the differentiation of hematopoietic stem cells into
lineage committed progenitors, ultimately generating mature B cells. This highly regulated …