The neuropeptide kisspeptin regulates reproduction by stimulating gonadotropin-releasing
hormone (GnRH) neurons via the kisspeptin receptor KISS1R. In addition to GnRH neurons …

Kisspeptin regulates reproduction via signaling through the receptor, Kiss1r, in GnRH
neurons. However, both kisspeptin and Kiss1r are produced in several peripheral tissues …

Kisspeptin is a neuropeptide with a critical role in the function of the hypothalamic–pituitary–
gonadal (HPG) axis. Kisspeptin is produced by two major populations of neurons located in …

Kisspeptin (encoded by the Kiss1 gene) and its receptor, KISS1R (encoded by the Kiss1r
gene), have well-established roles in stimulating reproduction via central actions on …

Abstract Background Kisspeptins, encoded by Kiss1, have emerged as essential regulators
of puberty and reproduction by primarily acting on GnRH neurons, via their canonical …

Landmark studies have shown that mutations in kisspeptin and the kisspeptin receptor
(Kiss1r) result in reproductive dysfunction in humans and genetically altered mouse models …

Kisspeptin was initially identified as a metastasis suppressor. Shortly after the initial
discovery, a key physiologic role for kisspeptin emerged in the regulation of fertility, with …

While kisspeptin was initially found to function as a metastasis suppressor, after
identification of its receptor KISS1R and their expression profiles in tissues such as the …

Aims To investigate the effect of kisspeptin on glucose‐stimulated insulin secretion and
appetite in humans. Materials and methods In 15 healthy men (age: 25.2±1.1 years; BMI …

Unraveling of the master role of kisspeptins, the products of the KiSS-1 gene, and their
receptor, GPR54, in the control of reproduction has been a major breakthrough in …