The neurohormonal control of reproduction involves a hierarchical network of central and
peripheral signals in the hypothalamic–pituitary–gonadal (HPG) axis. Development and …

The present study aimed to evaluate whether novel conditional kisspeptin neuron-specific
Kiss1 knockout (KO) mice utilizing the Cre-loxP system could recapitulate the infertility of …

Kisspeptin and its G protein-coupled receptor KISS1R play key roles in mammalian
reproduction due to their involvement in the onset of puberty and control of the hypothalamic …

Neurons that produce gonadotropin-releasing hormone (GnRH) reside in the basal
forebrain and drive reproductive function in mammals. Understanding the circuitry that …

Kisspeptin is essential in reproduction and acts by stimulating neurones expressing
gonadotrophin‐releasing hormone (GnRH). Recent studies suggest that kisspeptin has …

Hypogonadotropism is a common feature of uncontrolled diabetes, for which the ultimate
mechanism remains to be elucidated. Kisspeptins, ligands of G protein–coupled receptor 54 …

The Kiss1 gene codes for kisspeptin, which binds to GPR54, a G-protein-coupled receptor.
Kisspeptin and GPR54 are expressed in discrete regions of the forebrain, and they have …

Kisspeptin, encoded by KISS1/Kiss1 gene, is now considered a master regulator of
reproductive functions in mammals owing to its involvement in the direct activation of …

Reproduction requires adequate energy stores for parents and offspring to survive. Kiss1
neurons, which are essential for fertility, have the potential to serve as the central sensors of …

Kisspeptin (a product of the Kiss1 gene) and its receptor (GPR54 or Kiss1r) have emerged
as key players in the regulation of reproduction. Mutations in humans or genetically targeted …