It is well established that reproductive function is gated by the state of energy reserves of the
organism; conditions of metabolic stress and energy insufficiency being frequently coupled …

Hypothalamic KiSS-1 gene expression is critical for the maintenance of reproductive
function, and levels are attenuated by sex hormones and by food restriction, providing a link …

Kisspeptin (encoded by KISS1) is a crucial activator of reproductive function. The role of
kisspeptin has been studied extensively within the hypothalamus but little is known about its …

Introduction Kisspeptin, which is encoded by the KISS1 gene and acts via GPR54, plays a
role in the regulation of reproductive functions. Expression of KISS1 and GRPR54 has been …

Kisspeptin binding to its G-protein-coupled receptor KISS1R (also known as GPR54), which
is expressed by gonadotropin-releasing hormone (GnRH) neurons, stimulates GnRH …

Pubertal onset only occurs in a favorable, anabolic hormonal environment. The
neuropeptide kisspeptin, encoded by the Kiss1 gene, modifies GnRH neuronal activity to …

Kisspeptin, identified as a natural ligand of GPR54 in 2001, is now considered as a master
regulator of puberty and subsequent reproductive functions in mammals. Our previous …

The Kiss1 gene encodes a family of peptides called kisspeptins, which bind to the G protein-
coupled receptor GPR54. Kisspeptin (s) and its receptor are expressed in the forebrain, and …

Results The kisspeptin system (KISS1/G protein-coupled receptor-54, GPR54) has recently
been addressed as an essential gatekeeper of puberty onset and gonadotropin secretion …

Kisspeptin (encoded by the Kiss1 gene) is an important regulator of reproduction. In rodents,
Kiss1 is expressed in two hypothalamic regions, the arcuate nucleus and anteroventral …