Mechanisms underpinning sympathoexcitation in hypoxia

LL Simpson, M Stembridge… - The Journal of …, 2024 - Wiley Online Library
Sympathoexcitation is a hallmark of hypoxic exposure, occurring acutely, as well as
persisting in acclimatised lowland populations and with generational exposure in highland …

A sympathetic view of blood pressure control at high altitude: new insights from microneurographic studies

LL Simpson, CD Steinback… - Experimental …, 2021 - Wiley Online Library
New Findings What is the topic of the review? Sympathoexcitation and sympathetic control
of blood pressure at high altitude. What advances does it highlight? Sustained …

Sympathetic neural overactivity in healthy humans after prolonged exposure to hypobaric hypoxia

J Hansen, M Sander - The Journal of physiology, 2003 - Wiley Online Library
Acute exposure to hypoxia causes chemoreflex activation of the sympathetic nervous
system. During acclimatization to high altitude hypoxia, arterial oxygen content recovers, but …

Carotid chemoreceptor control of muscle sympathetic nerve activity in hypobaric hypoxia

JP Fisher, D Flück, MP Hilty… - Experimental physiology, 2018 - Wiley Online Library
New Findings What is the central question of this study? High‐altitude hypoxia increases
muscle sympathetic nerve activity (MSNA), but whether intravenous infusion of dopamine, to …

Sustained sympathetic activity in altitude acclimatizing lowlanders and high‐altitude natives

C Lundby, J Calbet, G Van Hall… - … journal of medicine & …, 2018 - Wiley Online Library
Combined results from different independent studies suggest that acclimatization to high
altitude induces a slowly developing sympathetic activation, even at levels of hypoxia that …

Does the sympathetic nervous system adapt to chronic altitude exposure?

M Sander - Hypoxia: Translation in Progress, 2016 - Springer
During continued exposure to hypobaric hypoxia in acclimatizing lowlanders increasing
norepinephrine levels indirectly indicate sympathoexcitation, and in a few subjects serial …

Influence of sympathoexcitation at high altitude on cerebrovascular function and ventilatory control in humans

PN Ainslie, SJE Lucas, JL Fan… - Journal of Applied …, 2012 - journals.physiology.org
We sought to determine the influence of sympathoexcitation on dynamic cerebral
autoregulation (CA), cerebrovascular reactivity, and ventilatory control in humans at high …

Baroreflex control of sympathetic vasomotor activity and resting arterial pressure at high altitude: insight from Lowlanders and Sherpa

LL Simpson, SA Busch, SJ Oliver… - The Journal of …, 2019 - Wiley Online Library
Key points Hypoxia, a potent activator of the sympathetic nervous system, is known to
increase muscle sympathetic nerve activity (MSNA) to the peripheral vasculature of native …

Duration at high altitude influences the onset of arrhythmogenesis during apnea

LF Berthelsen, S Van Diepen, AR Steele… - European Journal of …, 2022 - Springer
Purpose Autonomic control of the heart is balanced by sympathetic and parasympathetic
inputs. Excitation of both sympathetic and parasympathetic systems occurs concurrently …

Baroreflex and chemoreflex interaction in high-altitude exposure: possible role on exercise performance

P Alvarez-Araos, S Jiménez, C Salazar-Ardiles… - Frontiers in …, 2024 - frontiersin.org
The hypoxic chemoreflex and the arterial baroreflex are implicated in the ventilatory
response to exercise. It is well known that long-term exercise training increases …