Lowland-dwelling populations exhibit persistent sympathetic hyperactivity at altitude that
alters vascular function. High-altitude populations, such as Sherpa, have previously …

Alterations in cardiovascular and respiratory function are extremely important as we ascend
to high altitude since the associated hypoxia leads to tachycardia, increased cardiac output …

Hypoxia may sensitize the carotid chemoreceptors, resulting in a sustained elevation of
muscle sympathetic nerve activity (MSNA) that outlasts the hypoxic stimulus. To test this …

The combined effects of hypoxia and hypercapnia on the sympathetic nervous system were
investigated in nine healthy subjects. Each subject was exposed to 16 gas mixtures in …

Pulmonary edema (PE) is an issue widely noted in acute exposure to hypoxia as seen in
high altitude climbers, yet the etiology of this is not defined. Previous studies in rats showed …

Apnea divers are exposed to repeated massive arterial oxygen desaturation, which could
perturb chemoreflexes. An earlier study suggested that peripheral chemoreflex regulation of …

We sought to determine whether chronic exposure to intermittent hypoxia (CIH) increases
sympathetic responsiveness to subsequent chemoreflex stimulation. Sprague-Dawley rats …

It is well known that the respiration modulates sympathetic outflow in basal conditions.
Recordings of sympathetic nerve activity demonstrated that central respiratory activity …

The ventilatory response to hypoxia is complex. First contact with hypoxia causes an
increase in ventilation within seconds that reaches full intensity within minutes because of …

Hypoxia is a pivotal factor in the pathophysiology of various clinical conditions, including
obstructive sleep apnea, which has a strong association with cardiovascular diseases like …