Detoxified pertussis toxin (pertussis toxoid) is a major antigen in acellular pertussis
vaccines. Testing these vaccines on the presence of residual pertussis toxin (PTx) and …

The mouse histamine sensitization test (HIST) is the currently accepted regulatory method
used to monitor residual pertussis toxin (PTx) activity in acellular pertussis vaccines. This …

Testing for inactivation of pertussis toxin and reversion to toxicity in aP vaccines has
historically relied on the murine histamine sensitization test, that lacks mechanistic …

Because of the exquisite sensitivity of the murine histamine sensitization test (HIST) in
detecting minute amounts of active pertussis toxin (PTx), this animal-based test has been …

A binding assay was recently published that differentiates between pertussis toxin (PTx) and
the pertussis toxoid (PTd) used in acellular pertussis vaccines based on the selective …

All acellular pertussis (aP) vaccines in use contain chemically inactivated pertussis toxin
(PT). The finding that mice, naturally resistant to the effects of histamine, become sensitive …

Safety requirements stipulate the performance of the in vivo Histamine Sensitization (HS)
test for quality control of acellular pertussis (aP) vaccines. For reasons of reproducibility and …

The histamine sensitization test is a widely used method for measuring the residual toxicity
of pertussis toxin in acellular pertussis vaccines. Although it has been used as a routine …

Regulatory authorities require safety and potency testing prior to the release of each
production lot of acellular pertussis (aP)-containing vaccines. Currently, the murine …

Pertussis vaccines are routinely administered to infants to protect them from whooping
cough. Still, an adequate safety test for pertussis toxin (PT), one of the main antigens in …