Is Interleukin-38 a key player cytokine in atherosclerosis immune gene therapy?

A Esmaeilzadeh, S Pouyan, M Erfanmanesh - Medical hypotheses, 2019 - Elsevier
Atherosclerosis, a chronic inflammatory disease of the arteries associated with lipids and
other metabolic alterations is a leading cause of death all around the world and its rate is …

The role of interleukin 35 in atherosclerosis

J Lin, V Kakkar, X Lu - Current pharmaceutical design, 2015 - ingentaconnect.com
Atherosclerosis has been widely recognized as a slow progressing inflammatory disease of
the arterial walls involving both inflammation and autoimmune processes with a complex …

IL-38 in modulating hyperlipidemia and its related cardiovascular diseases

M Lai, H Peng, X Wu, X Chen, B Wang, X Su - International …, 2022 - Elsevier
Hyperlipidemia is confirmed to be associated with several health problems that include the
combination of diabetes mellitus, obesity, and hypertension, ie, metabolic syndrome …

Interleukin 17, the double-edged sword in atherosclerosis

A Moeinafshar, S Razi, N Rezaei - Immunobiology, 2022 - Elsevier
Cardiovascular diseases, including atherosclerosis, are the number one cause of death
worldwide. These diseases have taken the place of pneumonia and other infectious …

Novel anti-inflammatory interleukin-35 as an emerging target for antiatherosclerotic therapy

YV Bobryshev, IA Sobenin… - Current …, 2015 - ingentaconnect.com
Atherosclerosis has been widely recognized as a slow progressing inflammatory disease of
the aorta and other large caliber arterial vessels. Accumulating evidence suggest that …

Interleukin-38 in atherosclerosis

XH Zhang, Y Li, L Zhou, GP Tian - Clinica Chimica Acta, 2022 - Elsevier
Chronic inflammation caused by immune cells and their mediators is a characteristic of
atherosclerosis. Interleukin-38 (IL-38), a member of the IL-1 family, exerts multiple anti …

Interleukin‐37: the effect of anti‐inflammatory response in human coronary artery endothelial cells

X Yan, B Xie, G Wu, J Hu, D Wang… - Mediators of …, 2019 - Wiley Online Library
Interleukin‐37 (IL‐37) is unique in the IL‐1 family since it broadly suppresses innate
immunity and elevates in humans with inflammatory and autoimmune diseases. IL‐37 …

Interleukin-35 ameliorates cardiovascular disease by suppressing inflammatory responses and regulating immune homeostasis

J Feng, Y Wu - International Immunopharmacology, 2022 - Elsevier
The immune response is of great significance in the initiation and progression of a diversity
of cardiovascular diseases involving pro-and anti-inflammatory cytokines. Interleukin-35 (IL …

Blockade of interleukin-12 function by protein vaccination attenuates atherosclerosis

AD Hauer, C Uyttenhove, P De Vos, V Stroobant… - Circulation, 2005 - Am Heart Assoc
Background—Interleukin-12 (IL-12) has been identified as a key inducer of a type 1 T-helper
cell cytokine pattern, which is thought to contribute to the development of atherosclerosis …

The biological function and significance of IL-35 in the pathogenesis of atherosclerosis

M Staciwa, M Broncel - Polski Merkuriusz Lekarski: Organ …, 2018 - europepmc.org
The imbalance of anti-inflammatory/pro-inflammatory cytokines plays an important role in the
progression of atherosclerosis. Interleukin 35 (IL-35) is a novel member of the IL-12 family …