On the Role of CD8+ T Cells in Determining Recovery Time from Influenza Virus Infection

P Cao, Z Wang, AWC Yan, J McVernon, J Xu… - Frontiers in …, 2016 - frontiersin.org
Myriad experiments have identified an important role for CD8+ T cell response mechanisms
in determining recovery from influenza A virus infection. Animal models of influenza infection …

Mathematical model reveals the role of memory CD8 T cell populations in recall responses to influenza

VI Zarnitsyna, A Handel, SR McMaster… - Frontiers in …, 2016 - frontiersin.org
The current influenza vaccine provides narrow protection against the strains included in the
vaccine, and needs to be reformulated every few years in response to the constantly …

Dynamically linking influenza virus infection kinetics, lung injury, inflammation, and disease severity

MA Myers, AP Smith, LC Lane, DJ Moquin, R Aogo… - Elife, 2021 - elifesciences.org
Influenza viruses cause a significant amount of morbidity and mortality. Understanding host
immune control efficacy and how different factors influence lung injury and disease severity …

Simulation and prediction of the adaptive immune response to influenza A virus infection

HY Lee, DJ Topham, SY Park, J Hollenbaugh… - Journal of …, 2009 - Am Soc Microbiol
The cellular immune response to primary influenza virus infection is complex, involving
multiple cell types and anatomical compartments, and is difficult to measure directly. Here …

Innate immunity and the inter-exposure interval determine the dynamics of secondary influenza virus infection and explain observed viral hierarchies

P Cao, AWC Yan, JM Heffernan, S Petrie… - PLoS computational …, 2015 - journals.plos.org
Influenza is an infectious disease that primarily attacks the respiratory system. Innate
immunity provides both a very early defense to influenza virus invasion and an effective …

Assessing mathematical models of influenza infections using features of the immune response

HM Dobrovolny, MB Reddy, MA Kamal, CR Rayner… - PloS one, 2013 - journals.plos.org
The role of the host immune response in determining the severity and duration of an
influenza infection is still unclear. In order to identify severity factors and more accurately …

Quantifying the early immune response and adaptive immune response kinetics in mice infected with influenza A virus

H Miao, JA Hollenbaugh, MS Zand… - Journal of …, 2010 - Am Soc Microbiol
Seasonal and pandemic influenza A virus (IAV) continues to be a public health threat.
However, we lack a detailed and quantitative understanding of the immune response …

Modeling within-host dynamics of influenza virus infection including immune responses

KA Pawelek, GT Huynh, M Quinlivan… - PLoS computational …, 2012 - journals.plos.org
Influenza virus infection remains a public health problem worldwide. The mechanisms
underlying viral control during an uncomplicated influenza virus infection are not fully …

Model of influenza A virus infection: dynamics of viral antagonism and innate immune response

M Fribourg, B Hartmann, M Schmolke… - Journal of theoretical …, 2014 - Elsevier
Viral antagonism of host responses is an essential component of virus pathogenicity. The
study of the interplay between immune response and viral antagonism is challenging due to …

Modelling cross-reactivity and memory in the cellular adaptive immune response to influenza infection in the host

AWC Yan, P Cao, JM Heffernan, J McVernon… - Journal of Theoretical …, 2017 - Elsevier
The cellular adaptive immune response plays a key role in resolving influenza infection.
Experiments where individuals are successively infected with different strains within a short …