Corticotropin-releasing factor (CRF) neurons in the hypothalamic paraventricular nucleus
(PVN) initiate hypothalamic–pituitary–adrenal axis activity through the release of CRF into …

The genetic architecture of psychiatric disorders is characterized by a large number of small-
effect variants located primarily in non-coding regions, suggesting that the underlying causal …

Fast-acting neurotransmitters and slow, modulatory neuropeptides are co-released from
neurons in the central nervous system, albeit from distinct synaptic vesicles. The …

Combining rabies-virus tracing, optical clearing (CLARITY), and whole-brain light-sheet
imaging, we mapped the monosynaptic inputs to midbrain dopamine neurons projecting to …

Oestrogen receptor alpha (ERα) signalling in the ventromedial hypothalamus (VMH)
contributes to energy homeostasis by modulating physical activity and thermogenesis …

Leptin, a hormone produced in white adipose tissue, acts in the brain to communicate fuel
status, suppress appetite following a meal, promote energy expenditure and maintain blood …

The paraventricular nucleus of the hypothalamus (PVH) contains a heterogeneous cluster of
Sim1-expressing cell types that comprise a major autonomic output nucleus and play critical …

Pro‐opiomelanocortin (POMC) neurones within the hypothalamic arcuate nucleus are vital
anorexigenic neurones. Both the insulin receptor and leptin receptor are coupled to …

The paraventricular nucleus of the hypothalamus (PVH) consists of distinct functional
compartments regulating neuroendocrine, behavioral, and autonomic activities that are …

Leptin is critical for energy balance, glucose homeostasis, and for metabolic and
neuroendocrine adaptations to starvation. A prevalent model predicts that leptin's actions …