Endothelial cells are, by number, one of the most abundant cell types in the heart and active
players in cardiac physiology and pathology. Coronary angiogenesis plays a vital role in …

Cardiac hypertrophy is an adaptive response to physiological and pathological overload. In
response to the overload, individual cardiac myocytes become mechanically stretched and …

Background: Heart failure, which is a major global health problem, is often preceded by
pathological cardiac hypertrophy. The expansion of the cardiac vasculature, to maintain …

Pathological cardiac hypertrophy is a key risk factor for the development of heart failure and
predisposes individuals to cardiac arrhythmia and sudden death. While physiological …

Heart failure is a complex medical syndrome that is attributed to a number of risk factors;
nevertheless, its clinical presentation is quite similar among the different etiologies. Heart …

Recently, a new paradigm for the development of heart failure with preserved ejection
fraction (HFpEF) has been proposed, which identifies a systemic pro-inflammatory state …

It is well established that the vasculature plays a crucial role in maintaining oxygen and
nutrients supply to the heart. Increasing evidence further suggests that the microcirculation …

The heart is a highly structured organ consisting of different cell types, including myocytes,
endothelial cells, fibroblasts, stem cells, and inflammatory cells. This pluricellularity provides …

Experimental work during the past 15 years has demonstrated that endothelial cells in the
heart play an obligatory role in regulating and maintaining cardiac function, in particular, at …

The heart must continuously pump blood to supply the body with oxygen and nutrients. To
maintain the high energy consumption required by this role, the heart is equipped with …