[HTML][HTML] Partial Synthetic PPARƳ Derivative Ameliorates Aorta Injury in Experimental Diabetic Rats Mediated by Activation of miR-126-5p Pi3k/AKT/PDK 1/mTOR …
Type 2 diabetes mellitus (T2D) is a world wild health care issue marked by insulin
resistance, a risk factor for the metabolic disorder that exaggerates endothelial dysfunction …
resistance, a risk factor for the metabolic disorder that exaggerates endothelial dysfunction …
PPARδ activation protects endothelial function in diabetic mice
Recent evidence highlights the therapeutic potential of peroxisome proliferator–activated
receptor-δ (PPARδ) agonists to increase insulin sensitivity in diabetes. However, the role of …
receptor-δ (PPARδ) agonists to increase insulin sensitivity in diabetes. However, the role of …
PPARdelta activation protects endothelial function in diabetic mice via PI3K/Akt/eNOS signaling pathway
WT Wong, XY Tian, Y Huang - 2011 - Am Heart Assoc
Introduction: Recent evidence highlights therapeutic potentials of peroxisome proliferator-
activated receptor-delta (PPARdelta) agonists to increase insulin sensitivity in diabetes. The …
activated receptor-delta (PPARdelta) agonists to increase insulin sensitivity in diabetes. The …
Activation of peroxisome proliferator-activated receptor-β/-δ (PPARβ/δ) prevents endothelial dysfunction in type 1 diabetic rats
AM Quintela, R Jimenez, M Gomez-Guzman… - Free Radical Biology …, 2012 - Elsevier
Endothelial dysfunction plays a key role in the pathogenesis of diabetic vascular disease.
Herein, we have analyzed if the peroxisome proliferator-activated receptor-β/-δ (PPARβ/δ) …
Herein, we have analyzed if the peroxisome proliferator-activated receptor-β/-δ (PPARβ/δ) …
Pharmacological activation of PPAR gamma ameliorates vascular endothelial insulin resistance via a non-canonical PPAR gamma-dependent nuclear factor-kappa B …
Y Zhang, RX Zhan, JQ Chen, Y Gao, L Chen… - European journal of …, 2015 - Elsevier
Vascular endothelial insulin resistance (IR) is a critically initial factor in
cardiocerebrovascular events resulted from diabetes and is becoming a worldwide public …
cardiocerebrovascular events resulted from diabetes and is becoming a worldwide public …
New PPARγ partial agonist improves obesity-induced metabolic alterations and atherosclerosis in LDLr−/− mice
JC Silva, FA César, EM de Oliveira, WM Turato… - Pharmacological …, 2016 - Elsevier
Peroxisome proliferator-activated receptor gamma (PPARγ) regulates multiple pathways
involved in the pathogenesis of obesity and atherosclerosis. Here, we evaluated the …
involved in the pathogenesis of obesity and atherosclerosis. Here, we evaluated the …
Newly developed PPAR-α agonist (R)-K-13675 inhibits the secretion of inflammatory markers without affecting cell proliferation or tube formation
K Kitajima, S Miura, Y Mastuo, Y Uehara, K Saku - Atherosclerosis, 2009 - Elsevier
Peroxisome proliferator-activated receptor-alpha (PPAR-α) is a key regulator of lipid and
glucose metabolism and has been implicated in inflammation. The vascular effects of …
glucose metabolism and has been implicated in inflammation. The vascular effects of …
Metformin protects endothelial function in diet-induced obese mice by inhibition of endoplasmic reticulum stress through 5′ adenosine monophosphate–activated …
Objective—5′ Adenosine monophosphate–activated protein kinase (AMPK) interacts with
peroxisome proliferator–activated receptor δ (PPARδ) to induce gene expression …
peroxisome proliferator–activated receptor δ (PPARδ) to induce gene expression …
[HTML][HTML] Pioglitazone attenuates atherosclerosis in diabetic mice by inhibition of receptor for advanced glycation end-product (RAGE) signaling
H Gao, H Li, W Li, X Shen, B Di - Medical Science Monitor …, 2017 - ncbi.nlm.nih.gov
Background Peroxisome proliferator-activated receptor-γ (PPAR-γ) exhibits anti-
inflammatory and anti-diabetic properties, and is protective against cardiovascular diseases …
inflammatory and anti-diabetic properties, and is protective against cardiovascular diseases …
[HTML][HTML] Vasculoprotective effects of rosiglitazone through modulating renin-angiotensin system in vivo and vitro
L Ren, N Liu, H Zhi, Y Li, Y Li, R Tang… - Cardiovascular …, 2011 - Springer
Background The peroxisome proliferator-activated receptor-γ (PPARγ) agonist rosiglitazone
has been suggested to exert cardiovascular protection through the improvement of lipid …
has been suggested to exert cardiovascular protection through the improvement of lipid …