In an 8-week, placebo-controlled multicenter study, the efficacy of dose levels of simvastatin
2.5, 5, 10, 20, and 40 mg was evaluated in 166 patients with hypercholesterolemia, of whom …

Fluvastatin sodium (Lescol) is the first synthetic 3-hydroxy-3-methylglutaryl-coenzyme A
(HMGCoA)-reductase inhibitor to be studied extensively in humans. Absorption of fluvastatin …

Background: Atorvastatin, a new enantiomerically pure synthetic statin, has shown a marked
low-density lipoprotein (LDL) cholesterol reduction at doses ranging from 10 to 80 mg/d …

This analysis assessed the safety of atorvastatin in the 10-to 80-mg dose range using
pooled data from 44 completed trials comprising 16,495 dyslipidemic patients treated with …

Seventy-seven hypercholesterolemic patients participated in a 26-week, multicenter,
randomized, double-blind, placebo-controlled study that investigated the efficacy and safety …

A simple, sensitive, selective and rapid liquid chromatography–tandem mass spectrometry
(LC‐MS/MS) method was developed and validated for the quantification of atorvastatin and …

BACKGROUND: Previous studies have shown that effects on high-density lipoprotein
cholesterol (HDL-C) may differ among statins. METHODS: A multicenter, randomized …

The disposition of a single 20‐mg oral dose of pravastatin was assessed in subjects with
various degrees of renal function. Sixteen subjects (13 males, 3 females) with creatinine …

BACKGROUND: The NASDAC study was designed to evaluate the safety and efficacy of
atorvastatin at starting doses of 10, 20, 40, and 80 mg. METHODS: After an 8-week placebo …

Administration of high doses of atorvastatin 80 mg/day and rosuvastatin 40 mg/day is a part
of a standard algorithm for the treatment of patients at high and very high cardiovascular risk …