Aryl hydrocarbon receptor (AhR)-dependent regulation of pulmonary miRNA by chronic cigarette smoke exposure
S Rogers, AR de Souza, M Zago, M Iu, N Guerrina… - Scientific reports, 2017 - nature.com
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor historically
known for its toxic responses to man-made pollutants such as dioxin. More recently, the AhR …
known for its toxic responses to man-made pollutants such as dioxin. More recently, the AhR …
Aryl hydrocarbon receptor-dependent regulation of miR-196a expression controls lung fibroblast apoptosis but not proliferation
E Hecht, M Zago, M Sarill, AR de Souza… - Toxicology and applied …, 2014 - Elsevier
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor implicated in
the regulation of apoptosis and proliferation. Although activation of the AhR by xenobiotics …
the regulation of apoptosis and proliferation. Although activation of the AhR by xenobiotics …
Aryl hydrocarbon receptor-dependent retention of nuclear HuR suppresses cigarette smoke-induced cyclooxygenase-2 expression independent of DNA-binding
M Zago, JA Sheridan, P Nair, A Rico de Souza… - PLoS …, 2013 - journals.plos.org
The aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor that responds to
man-made environmental toxicants, has emerged as an endogenous regulator of …
man-made environmental toxicants, has emerged as an endogenous regulator of …
Low levels of the AhR in chronic obstructive pulmonary disease (COPD)-derived lung cells increases COX-2 protein by altering mRNA stability
M Zago, JA Sheridan, H Traboulsi, E Hecht, Y Zhang… - PLoS …, 2017 - journals.plos.org
Heightened inflammation, including expression of COX-2, is associated with chronic
obstructive pulmonary disease (COPD) pathogenesis. The aryl hydrocarbon receptor (AhR) …
obstructive pulmonary disease (COPD) pathogenesis. The aryl hydrocarbon receptor (AhR) …
Where the aryl hydrocarbon receptor meets the microRNAs: literature review of the last 10 years
The aryl hydrocarbon receptor (AhR) is an environmentally responsive ligand-activated
transcription factor, identified in the '70s for its toxic responses to halogenated polycyclic …
transcription factor, identified in the '70s for its toxic responses to halogenated polycyclic …
Aryl hydrocarbon receptor protects lung adenocarcinoma cells against cigarette sidestream smoke particulates-induced oxidative stress
YH Cheng, SC Huang, CJ Lin, LC Cheng… - Toxicology and applied …, 2012 - Elsevier
Environmental cigarette smoke has been suggested to promote lung adenocarcinoma
progression through aryl hydrocarbon receptor (AhR)-signaled metabolism. However …
progression through aryl hydrocarbon receptor (AhR)-signaled metabolism. However …
MicroRNAs as regulators of airborne pollution-induced lung inflammation and carcinogenesis
J Wei, F Li, J Yang, X Liu, WC Cho - Archives of Toxicology, 2015 - Springer
The increasing incidence of pulmonary inflammation and lung cancer, as well as
exacerbation of pre-existing chronic lung diseases by exposure to airborne pollutants, eg …
exacerbation of pre-existing chronic lung diseases by exposure to airborne pollutants, eg …
Aryl hydrocarbon receptor-deficient mice develop heightened inflammatory responses to cigarette smoke and endotoxin associated with rapid loss of the nuclear …
TH Thatcher, SB Maggirwar, CJ Baglole… - The American journal of …, 2007 - Elsevier
The transcription factor aryl hydrocarbon receptor (AhR) plays an important role in the
response to environmental pollutants. However, its role in normal physiology is unclear. To …
response to environmental pollutants. However, its role in normal physiology is unclear. To …
Persistence of smoking-induced dysregulation of miRNA expression in the small airway epithelium despite smoking cessation
G Wang, R Wang, Y Strulovici-Barel, J Salit, MR Staudt… - PloS one, 2015 - journals.plos.org
Even after quitting smoking, the risk of the development of chronic obstructive pulmonary
disease (COPD) and lung cancer remains significantly higher compared to healthy …
disease (COPD) and lung cancer remains significantly higher compared to healthy …
High miR203a-3p and miR-375 expression in the airways of smokers with and without COPD
J van Nijnatten, CA Brandsma, K Steiling… - Scientific Reports, 2022 - nature.com
Smoking is a leading cause of chronic obstructive pulmonary disease (COPD). It is known to
have a significant impact on gene expression and (inflammatory) cell populations in the …
have a significant impact on gene expression and (inflammatory) cell populations in the …