Core-fucosylation (CF) plays important roles in regulating biological processes in
eukaryotes. Alterations of CF-glycosites or CF-glycans in bodily fluids correlate with cancer …

Alterations in glycosylation of serum glycoproteins can provide unique and highly specific
fingerprints of malignancy. Our previous mass spectrometric study revealed that the …

Although lectin selection is gaining increasing acceptance as a tool for targeting
glycosylation in glycoproteomics, most of the work has been directed at N-glycosylation. The …

The majority of proteins present in human serum/plasma are glycoproteins, validating this
fluid as an ideal starting material for N-glycan analysis and discovery of potential …

Glycosylation is one the most common post-translational modifications (PTM) and
glycoproteins play fundamental roles in a diversity of biological processes. The development …

Site-specific glycosylation analysis is key to investigate structure-function relationships of
glycoproteins, eg in the context of antigenicity and disease progression. The analysis …

LC/MS is commonly used for site-specific glycosylation analysis of glycoproteins in cells and
tissues. A limitation of this technique is the difficulty in acquiring reliable mass spectra for …

Human serum has been intensively studied to identify biomarkers via global proteomic
analysis. The altered O-glycoproteome is associated with human pathological state …

Abstract Analysis of protein glycosylation is essential in order to correlate certain disease
types with oligosaccharide structures on proteins. Here, a method for the MS …

Serum N-glycans have been reported to be potential diagnostic and therapeutic biomarkers
for many diseases and conditions, such as inflammation, fibrosis, and cancer progression …