Targeting the tumor microenvironment to improve natural killer cell-based immunotherapies: On being in the right place at the right time, with resilience
S Murray, A Lundqvist - Human Vaccines & Immunotherapeutics, 2016 - Taylor & Francis
Natural killer (NK) cell immunotherapies that target solid tumors require NK cells in the
proper place, at the right time, with optimal function and a susceptible target cell. Basic …
proper place, at the right time, with optimal function and a susceptible target cell. Basic …
Influence of the tumor microenvironment on NK cell function in solid tumors
Natural killer (NK) cells are a population of innate lymphoid cells playing a pivotal role in
host immune responses against infection and tumor growth. These cells have a powerful …
host immune responses against infection and tumor growth. These cells have a powerful …
Natural killer cell-based therapies targeting cancer: possible strategies to gain and sustain anti-tumor activity
Natural killer (NK) cells were discovered 40 years ago, by their ability to recognize and kill
tumor cells without the requirement of prior antigen exposure. Since then, NK cells have …
tumor cells without the requirement of prior antigen exposure. Since then, NK cells have …
Tailoring Natural Killer cell immunotherapy to the tumour microenvironment
Natural killer (NK) cells are cytotoxic and cytokine-secreting cells that can mediate potent
anti-tumour activity. Accumulating evidence indicates that NK cell functions are severely …
anti-tumour activity. Accumulating evidence indicates that NK cell functions are severely …
Natural killer cells and solid tumors
A Stojanovic, A Cerwenka - Journal of innate immunity, 2011 - karger.com
Natural killer (NK) cells play an important role in the innate immune response against
cancer, in particular in the elimination of tumor metastases and small tumors. NK cell …
cancer, in particular in the elimination of tumor metastases and small tumors. NK cell …
Boosting natural killer cell-based immunotherapy with anticancer drugs: a perspective
Natural killer (NK) cells efficiently recognize and kill tumor cells through several mechanisms
including the expression of ligands for NK cell-activating receptors on target cells. Different …
including the expression of ligands for NK cell-activating receptors on target cells. Different …
Design and implementation of NK cell-based immunotherapy to overcome the solid tumor microenvironment
Simple Summary Cell therapy over the last few years has revolutionized the treatment of
blood cancers. However, efficacy against cancers of solid organs remains limited. These …
blood cancers. However, efficacy against cancers of solid organs remains limited. These …
Next generation immuno-oncology strategies: unleashing NK cells activity
A Mendoza-Valderrey, M Alvarez, A De Maria… - Cells, 2022 - mdpi.com
In recent years, immunotherapy has become a powerful therapeutic option against multiple
malignancies. The unique capacity of natural killer (NK) cells to attack cancer cells without …
malignancies. The unique capacity of natural killer (NK) cells to attack cancer cells without …
Natural killer cells in cancer biology and therapy
SY Wu, T Fu, YZ Jiang, ZM Shao - Molecular cancer, 2020 - Springer
The tumor microenvironment is highly complex, and immune escape is currently considered
an important hallmark of cancer, largely contributing to tumor progression and metastasis …
an important hallmark of cancer, largely contributing to tumor progression and metastasis …
Targeting natural killer cells for tumor immunotherapy
C Zhang, Y Hu, C Shi - Frontiers in immunology, 2020 - frontiersin.org
Natural killer (NK) cells are important innate cytotoxic lymphocytes with a rapid and efficient
capacity to recognize and kill tumor cells. In recent years, adoptive transfer of autologous-or …
capacity to recognize and kill tumor cells. In recent years, adoptive transfer of autologous-or …