Context-dependent signalling in platelets in vascular diseases: ROCK2 around thrombosis
JG Filep - Cardiovascular Research, 2017 - academic.oup.com
Platelets are best known as the cellular mediator of haemostasis and thrombosis. They also
possess immune and inflammatory functions that contribute to many vascular pathologies …
possess immune and inflammatory functions that contribute to many vascular pathologies …
Decreased thromboembolic stroke but not atherosclerosis or vascular remodelling in mice with ROCK2-deficient platelets
N Sladojevic, GT Oh, HH Kim… - Cardiovascular …, 2017 - academic.oup.com
Aims Rho-associated coiled-coil containing kinase (ROCK)-2 is an important mediator of the
actin cytoskeleton. Because changes in the actin cytoskeleton are critical for platelet …
actin cytoskeleton. Because changes in the actin cytoskeleton are critical for platelet …
Deficiency of ROCK1 in macrophages protects against atherosclerosis
HW Wang, N Oyama, Y Rikitake, S Kitamoto, J Gitlin… - 2007 - Am Heart Assoc
Background: Rho kinases (ROCKs) are serine-threonine protein kinases that regulate
various cellular functions. There is increasing evidence that the RhoA/ROCK pathway plays …
various cellular functions. There is increasing evidence that the RhoA/ROCK pathway plays …
Rho-Associated Coiled-Coil-Containing Kinase 2 Deficiency in Bone Marrow–Derived Cells Leads to Increased Cholesterol Efflux and Decreased Atherosclerosis
Q Zhou, Y Mei, T Shoji, X Han, K Kaminski, GT Oh… - Circulation, 2012 - Am Heart Assoc
Background—Macrophages play a central role in the development of atherosclerosis.
However, the signaling pathways that regulate their function are not well understood. The …
However, the signaling pathways that regulate their function are not well understood. The …
[HTML][HTML] ROCK2 Deficiency in Bone Marrow-Derived Cells Leads to Increased Cholesterol Efflux and Decreased Atherosclerosis
Q Zhou, Y Mei, T Shoji, X Han, K Kaminski, G Taeg… - Circulation, 2012 - ncbi.nlm.nih.gov
Background Macrophages play a central role in the development of atherosclerosis.
However, the signaling pathways that regulate their function are not well understood. The …
However, the signaling pathways that regulate their function are not well understood. The …
critical role of ROCK2 in bone marrow-derived macrophages in mediating atherosclerosis
Q Zhou, JK Liao - 2010 - Am Heart Assoc
Background: Rho kinases (ROCKs) are serine-threonine protein kinases that are involved in
the regulation of the actin cytoskeleton. Recent studies suggest that ROCKs also play a …
the regulation of the actin cytoskeleton. Recent studies suggest that ROCKs also play a …
[HTML][HTML] Deficiency of ROCK1 in bone marrow-derived cells protects against atherosclerosis in LDLR−/− mice
HW Wang, PY Liu, N Oyama, Y Rikitake… - The FASEB …, 2008 - ncbi.nlm.nih.gov
Rho kinases (ROCKs) are serine-threonine protein kinases that regulate the actin
cytoskeleton. Recent studies suggest that ROCKs also play an important role in …
cytoskeleton. Recent studies suggest that ROCKs also play an important role in …
ROCK1 mediates leukocyte recruitment and neointima formation following vascular injury
K Noma, Y Rikitake, N Oyama, G Yan… - The Journal of …, 2008 - Am Soc Clin Investig
Although Rho-associated kinase (ROCK) activity has been implicated in cardiovascular
diseases, the tissue-and isoform-specific roles of ROCKs in the vascular response to injury …
diseases, the tissue-and isoform-specific roles of ROCKs in the vascular response to injury …
[HTML][HTML] The function of Rho-associated kinases ROCK1 and ROCK2 in the pathogenesis of cardiovascular disease
S Hartmann, AJ Ridley, S Lutz - Frontiers in pharmacology, 2015 - frontiersin.org
Rho-associated kinases ROCK1 and ROCK2 are serine/threonine kinases that are
downstream targets of the small GTPases RhoA, RhoB, and RhoC. ROCKs are involved in …
downstream targets of the small GTPases RhoA, RhoB, and RhoC. ROCKs are involved in …
Rho kinase as a therapeutic target in cardiovascular disease
Rho kinase (ROCK) belongs to the AGC (PKA/PKG/PKC) family of serine/threonine kinases
and is a major downstream effector of the small GTPase RhoA. ROCK plays central roles in …
and is a major downstream effector of the small GTPase RhoA. ROCK plays central roles in …