Rho-associated coiled-coil-containing protein kinase (ROCK) is a serine/threonine kinase
that was originally identified as RhoA interacting protein. A diverse array of cellular …

Recently, we have read with great interest the published paper by Soliman et al.[1] and
subsequent correspondence by Tong et al.[2]. In Dr. Soliman et al.'s study, they found that …

Objective Rho‐associated kinase (ROCK) is a key regulator of numerous processes in
multiple cell types relevant in stroke pathophysiology. ROCK inhibitors have improved …

Background/Aims: This study used Rho-associated protein kinase (ROCK) isoform-selective
suppression or a ROCK inhibitor to analyze the roles of ROCK1 and ROCK2 in regulating …

Objective—Cardiovascular diseases are associated with chronic activation of Rho-
associated kinases (ROCKs) and endothelial dysfunction. Both increased ROCK activity and …

Abnormal proliferation and migration of vascular smooth muscle cells (VSMC) plays an
important role in vascular diseases. The Rho-associated protein kinase (ROCK) signaling …

Rho GTPases are critical for platelet function. Although the roles of RhoA, Rac and Cdc42
are characterized, platelets express other Rho GTPases, whose activities are less well …

Background—Rho GTPase and its downstream target, Rho-associated kinase (ROCK),
have been implicated in diverse cardiovascular diseases such as cardiac hypertrophy …

Although left ventricular (LV) diastolic dysfunction is often associated with hypertension, little
is known regarding its underlying pathophysiological mechanism. Here, we show that the …

Abstract 1060 Platelets serve as the primary mediators of hemostasis and thrombosis,
circulating as surveyors for gaps in vascular integrity. As platelets encounter exposed …