Evaluation of the Protective Effects of Sarains on H2O2-Induced Mitochondrial Dysfunction and Oxidative Stress in SH-SY5Y Neuroblastoma Cells

R Alvariño, E Alonso, MA Tribalat, S Gegunde… - Neurotoxicity …, 2017 - Springer
Sarains are diamide alkaloids isolated from the Mediterranean sponge Haliclona
(Rhizoniera) sarai that have previously shown antibacterial, insecticidal and anti-fouling …

Carnosic acid protects mitochondria of human neuroblastoma SH-SY5Y cells exposed to paraquat through activation of the Nrf2/HO-1Axis

MR de Oliveira, A Peres, GC Ferreira, PF Schuck… - Molecular …, 2017 - Springer
Abstract Carnosic acid (CA; C 20 H 28 O 4), which is also called salvin, is a major phenolic
diterpene found in Rosmarinus officinalis L. and exhibits antioxidant, anti-inflammatory, and …

Tanshinone I induces mitochondrial protection by a mechanism involving the Nrf2/GSH axis in the human neuroblastoma SH-SY5Y cells exposed to methylglyoxal

CR Fürstenau, ICC de Souza, MR de Oliveira - Neurotoxicity Research, 2019 - Springer
Methylglyoxal (MG) is a dicarbonyl molecule exhibiting high reactivity and is a major
responsible for glycation in human cells. Accumulation of MG is seen in certain diseases …

Puerarin Protects Human Neuroblastoma SH‐SY5Y Cells against Glutamate‐Induced Oxidative Stress and Mitochondrial Dysfunction

X Zhu, K Wang, K Zhang, X Lin, L Zhu… - Journal of Biochemical …, 2016 - Wiley Online Library
Glutamate, the principal excitatory neurotransmitter, plays a central role in brain metabolism;
however, aberrant neurotransmission of glutamate has been linked to neurodegenerative …

Sulforaphane promotes mitochondrial protection in SH-SY5Y cells exposed to hydrogen peroxide by an Nrf2-dependent mechanism

MR de Oliveira, F de Bittencourt Brasil… - Molecular …, 2018 - Springer
Abstract Sulforaphane (SFN; C 6 H 11 NOS 2) is an isothiocyanate found in cruciferous
vegetables, such as broccoli, kale, and radish. SFN exhibits antioxidant, anti-apoptotic, anti …

Tanshinone I induces mitochondrial protection through an Nrf2-dependent mechanism in paraquat-treatedhuman neuroblastoma SH-SY5Y cells

MR de Oliveira, PF Schuck, SMD Bosco - Molecular Neurobiology, 2017 - Springer
Abstract Tanshinone I (TI; 1, 6-Dimethylnaphtho [1, 2-g][1] benzofuran-10, 11-dione; C 18 H
12 O 3), which may be found in Salvia miltiorrhiza Bunge (Danshen), is a potent anti …

Sesamin and sesamol attenuate H2O2-induced oxidative stress on human neuronal cells via the SIRT1-SIRT3-FOXO3a signaling pathway

W Ruankham, W Suwanjang, P Wongchitrat… - Nutritional …, 2021 - Taylor & Francis
Background: An imbalance of free radicals and antioxidant defense systems in physiological
processes can result in protein/DNA damage, inflammation, and cellular apoptosis leading …

Saikosaponin-D mitigates oxidation in SH-SY5Y cells stimulated by glutamate through activation of Nrf2 pathway: involvement of PI3K

J Du, D Song, Y Li, J Liu, X Huang, B Li, L Li - Neurotoxicity Research, 2022 - Springer
Alzheimer's disease (AD) is a typical neurodegenerative disease. Well-established studies
have shown an elevated level of ROS (reactive oxygen species) that induces oxidative …

The Neuroprotective Effects of Ratanasampil on Oxidative Stress‐Mediated Neuronal Damage in Human Neuronal SH‐SY5Y Cells

A Zhu, Z Wu, J Meng, PL McGeer, Y Zhu… - Oxidative medicine …, 2015 - Wiley Online Library
We previously found that Ratanasampil (RNSP), a traditional Tibetan medicine, improves
the cognitive function of mild‐to‐moderate AD patients living at high altitude, as well as …

Ellagic acid mitigates arsenic‐trioxide‐induced mitochondrial dysfunction and cytotoxicity in SH‐SY5Y cells

F Firdaus, MF Zafeer, M Waseem, E Anis… - … of Biochemical and …, 2018 - Wiley Online Library
In the current study, neuroprotective significance of ellagic acid (EA, a polyohenol) was
explored by primarily studying its antioxidant and antiapoptotic potential against arsenic …