An optimized library for reference-based deconvolution of whole-blood biospecimens assayed using the Illumina HumanMethylationEPIC BeadArray
Genome-wide methylation arrays are powerful tools for assessing cell composition of
complex mixtures. We compare three approaches to select reference libraries for …
complex mixtures. We compare three approaches to select reference libraries for …
Enhanced cell deconvolution of peripheral blood using DNA methylation for high-resolution immune profiling
DNA methylation microarrays can be employed to interrogate cell-type composition in
complex tissues. Here, we expand reference-based deconvolution of blood DNA …
complex tissues. Here, we expand reference-based deconvolution of blood DNA …
Quantitative reconstruction of leukocyte subsets using DNA methylation
WP Accomando, JK Wiencke, EA Houseman… - Genome biology, 2014 - Springer
Background Cell lineage-specific DNA methylation patterns distinguish normal human
leukocyte subsets and can be used to detect and quantify these subsets in peripheral blood …
leukocyte subsets and can be used to detect and quantify these subsets in peripheral blood …
Improving cell mixture deconvolution by id entifying o ptimal dna methylation l ibraries (idol)
Background Confounding due to cellular heterogeneity represents one of the foremost
challenges currently facing Epigenome-Wide Association Studies (EWAS). Statistical …
challenges currently facing Epigenome-Wide Association Studies (EWAS). Statistical …
Blood-based profiles of DNA methylation predict the underlying distribution of cell types: a validation analysis
The potential influence of underlying differences in relative leukocyte distributions in studies
involving blood-based profiling of DNA methylation is well recognized and has prompted …
involving blood-based profiling of DNA methylation is well recognized and has prompted …
DNA methylation arrays as surrogate measures of cell mixture distribution
EA Houseman, WP Accomando, DC Koestler… - BMC …, 2012 - Springer
Background There has been a long-standing need in biomedical research for a method that
quantifies the normally mixed composition of leukocytes beyond what is possible by simple …
quantifies the normally mixed composition of leukocytes beyond what is possible by simple …
MethylResolver—a method for deconvoluting bulk DNA methylation profiles into known and unknown cell contents
Bulk tissue DNA methylation profiling has been used to examine epigenetic mechanisms
and biomarkers of complex diseases such as cancer. However, heterogeneity of cellular …
and biomarkers of complex diseases such as cancer. However, heterogeneity of cellular …
Cell-type deconvolution from DNA methylation: a review of recent applications
Recent advances in cell-type deconvolution approaches are adding to our understanding of
the biology underlying disease development and progression. DNA methylation (DNAm) …
the biology underlying disease development and progression. DNA methylation (DNAm) …
A meta-analysis of immune-cell fractions at high resolution reveals novel associations with common phenotypes and health outcomes
Background Changes in cell-type composition of tissues are associated with a wide range of
diseases and environmental risk factors and may be causally implicated in disease …
diseases and environmental risk factors and may be causally implicated in disease …
[PDF][PDF] High-resolution single-cell DNA methylation measurements reveal epigenetically distinct hematopoietic stem cell subpopulations
Increasing evidence of functional and transcriptional heterogeneity in phenotypically similar
cells examined individually has prompted interest in obtaining parallel methylome data. We …
cells examined individually has prompted interest in obtaining parallel methylome data. We …