Summary Interleukin 6 (IL-6) is a pleiotropic four-helix-bundle cytokine that exerts multiple
functions in the body. In the liver, IL-6 is an important inducer of the acute phase response …

ABSTRACT The interleukin 6 (IL6) family of proteins regulate important cellular processes
and act through a variety of signaling pathways via a shared gp130 receptor. In the liver …

Interleukins represent a class of immunomodulatory cytokines, small intercellular signaling
proteins, that are critically involved in the regulation of immune responses. They are …

Interleukin-6 (IL-6) has been suggested to play a pivotal role in liver regeneration. IL-6 on
target cells activates a receptor complex consisting of the IL-6 receptor (IL-6R) and the …

Background & Aims: Liver regeneration after loss of hepatic tissue leads to hepatocyte and
nonparenchymal cell proliferation and rapid restoration of liver parenchyma. Interleukin (IL) …

Chronic liver injury with any etiology can progress to fibrosis and the end-stage diseases
cirrhosis and hepatocellular carcinoma. The progression of liver disease is controlled by a …

IL-6 family cytokines are defined by the common use of the signal-transducing receptor
chain glycoprotein 130 (gp130). Increasing evidence indicates that these cytokines are …

The pyrogenic property being the first activity described, members of the interleukin-1
superfamily (IL-1α, IL-1β, IL-18, and the newest members: IL-33, IL-36, IL-37, and IL-38) are …

The multifunctional cytokine interleukin 6 (IL-6) is expressed in a wide variety of disease
states and pathologic processes. Mice deficient in IL-6 display abnormal and delayed liver …

The contribution of the acute phase inducer interleukin 6 (IL-6) in the pathogenesis of liver
diseases is yet unclear. Our analysis showed enhanced expression of IL-6 in livers derived …