Primary sclerosing cholangitis (PSC) is a chronic disease leading to fibrotic scarring of the
intrahepatic and extrahepatic bile ducts, causing considerable morbidity and mortality via …

Primary sclerosing cholangitis (PSC), first described in the mid-1850s, is a complex liver
disease that is heterogeneous in its presentation. PSC is characterized by chronic …

Primary sclerosing cholangitis (PSC) is a severe liver disease of unknown etiology leading
to fibrotic destruction of the bile ducts and ultimately to the need for liver transplantation,,. We …

Primary sclerosing cholangitis (PSC) is a rare autoimmune bile duct disease that is strongly
associated with immune-mediated disorders. In this study, we implemented multitrait joint …

Objective Primary sclerosing cholangitis (PSC) is a genetically complex, inflammatory bile
duct disease of largely unknown aetiology often leading to liver transplantation or death …

The pathogenesis of primary sclerosing cholangitis (PSC), a progressive biliary tract disease
without approved medical therapy, is not well understood. The relationship between PSC …

Primary sclerosing cholangitis (PSC) is a rare progressive disorder leading to bile duct
destruction;∼ 75% of patients have comorbid inflammatory bowel disease (IBD). We …

The aetiology of primary sclerosing cholangitis (PSC) is not known. A more than 80-fold
increased risk of PSC among first-degree relatives emphasizes the importance of genetic …

Primary Sclerosing Cholangitis: Epidemiology, Genetics, Diagnosis, and Current Management
Page 1 125 | CliniCal liver Disease, vOl 15, nO 3, MarCH 2020 An Official Learning Resource of …

An understanding of the immunobiology of primary sclerosing cholangitis (PSC) is essential
to improving both diagnosis and treatment. There have been significant gains in the …