Improvements in DNA sequencing technology and discoveries made by large scale genome-
wide association studies have led to enormous insight into the role of genetic variation in …

Prostate cancer (PC) has the highest degree of genetic transmission of any form of
malignancy. In some families, the hereditary pattern is so strong as to mimic an autosomal …

Simple Summary The potential importance of germline genetic variation for identifying men
at increased risk of prostate cancer has become increasingly recognised in recent years. We …

Abstract Purpose of Review Prostate cancer (PrCa) is the most common cancer in men in
the western world and is a major source of morbidity and mortality. Currently, general …

Objective Prostate cancer is the second most frequent cancer in men worldwide and kills
over 250,000 men worldwide every year. Prostate cancer is a heterogeneous disease at the …

BACKGROUND One of the difficulties confronting genetic studies of prostate cancer is the
complex and heterogeneous etiology. Given the high population frequency of lesions …

Prostate cancer is the second most common malignancy affecting men worldwide, and the
commonest affecting men of African descent. Significant diagnostic and therapeutic …

Few genetic risk factors have been demonstrated to be specifically associated with
aggressive prostate cancer (PrCa). Here, we report a case‐case study of PrCa comparing …

Worldwide, familial and epidemiological studies have generated considerable evidence of
an inherited component to prostate cancer. Indeed, rare highly penetrant genetic mutations …

Dramatic progress has been made in the area of germline genetics of prostate cancer (PCa)
in the past decade. Both common and rare genetic variants with effects on risk ranging from …