Tanshinone I Attenuates the Effects of a Challenge with H2O2 on the Functions of Tricarboxylic Acid Cycle and Respiratory Chain in SH-SY5Y Cells
MR de Oliveira, CR Fürstenau, ICC de Souza… - Molecular …, 2017 - Springer
Abstract Tanshinone I (TI; C 18 H 12 O 3) is a cytoprotective molecule. TI has been viewed
as an antioxidant and anti-inflammatory agent exerting neuroprotective actions in several …
as an antioxidant and anti-inflammatory agent exerting neuroprotective actions in several …
Carnosic Acid Suppresses the H2O2-Induced Mitochondria-Related Bioenergetics Disturbances and Redox Impairment in SH-SY5Y Cells: Role for Nrf2
The phenolic diterpene carnosic acid (CA, C 20 H 28 O 4) exerts antioxidant, anti-
inflammatory, anti-apoptotic, and anti-cancer effects in mammalian cells. CA activates the …
inflammatory, anti-apoptotic, and anti-cancer effects in mammalian cells. CA activates the …
Tanshinone I induces mitochondrial protection through an Nrf2-dependent mechanism in paraquat-treatedhuman neuroblastoma SH-SY5Y cells
MR de Oliveira, PF Schuck, SMD Bosco - Molecular Neurobiology, 2017 - Springer
Abstract Tanshinone I (TI; 1, 6-Dimethylnaphtho [1, 2-g][1] benzofuran-10, 11-dione; C 18 H
12 O 3), which may be found in Salvia miltiorrhiza Bunge (Danshen), is a potent anti …
12 O 3), which may be found in Salvia miltiorrhiza Bunge (Danshen), is a potent anti …
Naringenin Attenuates H2O2-Induced Mitochondrial Dysfunction by an Nrf2-Dependent Mechanism in SH-SY5Y Cells
MR de Oliveira, FB Brasil, CMB Andrade - Neurochemical Research, 2017 - Springer
Mitochondria are the major site of ATP production in mammalian cells. Furthermore, these
organelles are a source and a target of reactive oxygen species (ROS), such as radical …
organelles are a source and a target of reactive oxygen species (ROS), such as radical …
Tanshinone IIA and cryptotanshinone prevent mitochondrial dysfunction in hypoxia‐induced H9c2 cells: association to mitochondrial ROS, intracellular nitric oxide …
HJ Jin, CG Li - Evidence‐Based Complementary and …, 2013 - Wiley Online Library
The protective actions of tanshinones on hypoxia‐induced cell damages have been
reported, although the mechanisms have not been fully elucidated. Given the importance of …
reported, although the mechanisms have not been fully elucidated. Given the importance of …
Tanshinone I induces mitochondrial protection by a mechanism involving the Nrf2/GSH axis in the human neuroblastoma SH-SY5Y cells exposed to methylglyoxal
CR Fürstenau, ICC de Souza, MR de Oliveira - Neurotoxicity Research, 2019 - Springer
Methylglyoxal (MG) is a dicarbonyl molecule exhibiting high reactivity and is a major
responsible for glycation in human cells. Accumulation of MG is seen in certain diseases …
responsible for glycation in human cells. Accumulation of MG is seen in certain diseases …
Suppression of Mitochondria-Related Bioenergetics Collapse and Redox Impairment by Tanshinone I, a Diterpenoid Found in Salvia miltiorrhiza Bunge (Danshen) …
FB Brasil, FJS de Almeida, MD Luckachaki… - Neurotoxicity …, 2021 - Springer
Abstract Tanshinone I (TI, C 18 H 12 O 3) is a diterpene found in Salvia miltiorrhiza Bunge
(Danshen) and promotes cytoprotection in several experimental models. Chlorpyrifos (CPF) …
(Danshen) and promotes cytoprotection in several experimental models. Chlorpyrifos (CPF) …
Succinobucol, a lipid-lowering drug, protects against 3-nitropropionic acid-induced mitochondrial dysfunction and oxidative stress in SH-SY5Y cells via upregulation of …
D Colle, DB Santos, JM Hartwig, M Godoi… - Molecular …, 2016 - Springer
Succinobucol (succinyl ester of probucol) is a lipid-lowering compound with anti-
inflammatory and antioxidant properties. Recent experimental evidence has highlighted the …
inflammatory and antioxidant properties. Recent experimental evidence has highlighted the …
Sequential upregulation of superoxide dismutase 2 and heme oxygenase 1 by tert-butylhydroquinone protects mitochondria during oxidative stress
J Sun, X Ren, JW Simpkins - Molecular pharmacology, 2015 - ASPET
Oxidative stress is linked to mitochondrial dysfunction in aging and neurodegenerative
conditions. The transcription factor nuclear factor E2–related factor 2 (Nrf2)–antioxidant …
conditions. The transcription factor nuclear factor E2–related factor 2 (Nrf2)–antioxidant …
[HTML][HTML] The signaling pathway PI3K/Akt/Nrf2/HO-1 plays a role in the mitochondrial protection promoted by astaxanthin in the SH-SY5Y cells exposed to hydrogen …
FB Brasil, RCB Gobbo, FJS de Almeida… - Neurochemistry …, 2021 - Elsevier
The mitochondria are the major source of reactive species in the mammalian cells.
Hydrogen peroxide (H 2 O 2) is a potent inducer of redox impairment by a mechanism, at …
Hydrogen peroxide (H 2 O 2) is a potent inducer of redox impairment by a mechanism, at …