Statins, cardiovascular disease, and drug safety

AM Gotto Jr - The American journal of cardiology, 2006 - Elsevier
Available for almost 2 decades, the 3-hydroxy-3-methylglutaryl coenzyme A reductase
inhibitors, or statins, have emerged at the forefront of preventive drugs for cardiovascular …

[PDF][PDF] Statin Intolerance and the Obsession With Aggressive Cholesterol Lowering to Prevent Coronary Heart Disease

L Mascitelli, MR Goldstein - Journal of the American College of …, 2017 - researchgate.net
In a cohort of patients hospitalized for myocardial infarction (MI) at high death risk, Serban et
al.(1) found that statin intolerance was common in the year after initiation of therapy and that …

Strong Statins as the Major Players for Dyslipidemia in High-Risk Patients–Are They All the Same or Not?–

K Ikewaki, M Ayaori - Circulation Journal, 2011 - jstage.jst.go.jp
1327 Comparative Study of 3 Strong Statins ferase (ALT) was observed more frequently with
atorvastatin than with the other 2 statins. Although this significant difference diluted toward …

Who should receive a statin these days? Lessons from recent clinical trials

J Shepherd - Journal of internal medicine, 2006 - Wiley Online Library
The 3‐hydroxy‐3‐methylglutaryl coenzyme A reductase inhibitors or statins are the most
successful cardiovascular drugs of all time. By interrupting cholesterol synthesis in the liver …

Should all patients with cardiovascular disease receive statin therapy?

R Vogel, E Schaefer - The American Journal of Managed Care, 2001 - europepmc.org
With the strong correlation between the development of coronary heart disease and
elevated levels of total cholesterol and low-density lipoprotein cholesterol (LDL-C) …

The issue of statin safety: where do we stand?

SM Grundy - Circulation, 2005 - Am Heart Assoc
Statins are first-line therapy for reducing low-density lipoprotein (LDL) levels in patients at
high risk for atherosclerotic cardiovascular disease (ASCVD). 1, 2 These agents are being …

When choosing statin therapy: the case for generics

JB Green, JS Ross, CA Jackevicius… - JAMA internal …, 2013 - jamanetwork.com
The development of “Top 5” lists across specialties and at regular intervals can help to
remind physicians that optimal care is often possible at a lower cost. For purposes of …

Don't give more patients statins

JD Abramson, R RF - New York Times, 2013 - functionalmedicineuniversity.com
This announcement is not a result of a sudden epidemic of heart disease, nor is it based on
new data showing the benefits of lower cholesterol. Instead, it is a consequence of simply …

[PDF][PDF] Statin Adverse Effects

SG Mlodinow, MK Onysko, JW Vandiver, ML Hunter… - Circulation, 2014 - cdn.mdedge.com
Musculoskeletal symptoms are the most common AEs reported by patients who are taking
statins. 5 These range from muscle weakness, fatigue, and pain to (rarely) rhabdomyolysis …

Statin safety: an overview and assessment of the data—2005

H Bays - The American journal of cardiology, 2006 - Elsevier
The 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, or statin
drugs, have been studied in numerous controlled human research trials involving hundreds …