A comprehensive review on anticancer mechanisms of the main carotenoid of saffron, crocin

R Hoshyar, H Mollaei - Journal of Pharmacy and Pharmacology, 2017 - academic.oup.com
Objectives Crocin is derived from dried stigmas of Crocus sativus L.(saffron). It has long
been used to prevent and treat various diseases. Although crocin is suggested as one of the …

Crocetin and crocin from saffron in cancer chemotherapy and chemoprevention

A Colapietro, A Mancini… - Anti-Cancer Agents …, 2019 - ingentaconnect.com
Introduction: Cancer is a disorder which has a powerful impact on the quality life and life
expectancy despite the increase in drugs and treatments available for cancer patients …

The antileukemic effects of saffron (Crocus sativus L.) and its related molecular targets: A mini review

M Moradzadeh, MR Kalani… - Journal of cellular …, 2019 - Wiley Online Library
Abstract Saffron (Crocus sativus L.), and its main constituents, crocin, and crocetin have
shown promising effects as an antileukemic agent in animal models and cell culture …

Crocetin: an agent derived from saffron for prevention and therapy for cancer

WG Gutheil, G Reed, A Ray, S Anant… - Current pharmaceutical …, 2012 - ingentaconnect.com
Cancer is one of the leading causes of death in the United States and accounts for
approximately 8 million deaths per year worldwide. Although there is an increasing number …

Anti‐tumor effects of crocetin and related molecular targets

M Moradzadeh, HR Sadeghnia… - Journal of Cellular …, 2018 - Wiley Online Library
Natural products have gained a wide popularity as chemopreventive and anti‐cancer agents
owing to their multi‐mechanistic mode of action, availability and synergism with several …

Mechanism behind the anti-tumour potential of saffron (Crocus sativus L.): The molecular perspective

S Patel, M Sarwat, TH Khan - Critical Reviews in Oncology/Hematology, 2017 - Elsevier
Cancer is a disorder which has noted a significant rise in incidence worldwide and
continues to be the largest cause of mortality. It has a dramatic impact on human life …

[HTML][HTML] Role of crocin in several cancer cell lines: An updated review

A Veisi, G Akbari, SA Mard, G Badfar… - Iranian journal of …, 2020 - ncbi.nlm.nih.gov
Cancer is a major public health problem worldwide. The most important considerable
features of cancer cells are uncontrolled proliferation, up-regulated differentiation, and …

[HTML][HTML] Recent Advances on the Anticancer Properties of Saffron (Crocus sativus L.) and Its Major Constituents

A Lambrianidou, F Koutsougianni, I Papapostolou… - Molecules, 2020 - mdpi.com
Cancer is the second leading cause of death globally with an estimated 9.6 million deaths in
2018 and a sustained rise in its incidence in both developing and developed countries …

Crocin exhibits antitumor effects on human leukemia HL‐60 cells in vitro and in vivo

Y Sun, HJ Xu, YX Zhao, LZ Wang… - Evidence‐based …, 2013 - Wiley Online Library
Crocin is a carotenoid of the saffron extract that exhibits antitumor activity against many
human tumors. However, the effects of crocin on HL‐60 cells in vivo have not been …

Crocus sativus a natural food coloring and flavoring has potent anti-tumor properties

Z Khorasanchi, M Shafiee, F Kermanshahi, M Khazaei… - Phytomedicine, 2018 - Elsevier
Background Saffron, the dried stigmas of Crocus sativus L., is a highly valued agricultural
product that is used mainly as a food coloring and flavoring agent. Three main secondary …