Cigarette smoke and nicotine-containing electronic-cigarette vapor downregulate lung WWOX expression, which is associated with increased severity of murine acute …
Z Zeng, W Chen, A Moshensky, Z Shakir… - American journal of …, 2021 - atsjournals.org
A history of chronic cigarette smoking is known to increase risk for acute respiratory distress
syndrome (ARDS), but the corresponding risks associated with chronic e-cigarette use are …
syndrome (ARDS), but the corresponding risks associated with chronic e-cigarette use are …
Endothelial knockdown of the tumor suppressor, WWOX, increases inflammation in ventilator-induced lung injury
Z Zeng, E Abdelwahid, W Chen… - … of Physiology-Lung …, 2024 - journals.physiology.org
Chronic cigarette smoke exposure decreases lung expression of WWOX which is known to
protect the endothelial barrier during infectious models of acute respiratory distress …
protect the endothelial barrier during infectious models of acute respiratory distress …
[HTML][HTML] Loss of endothelial WWOX: a risk factor for ARDS in smokers?
K Tanimura, T Nyunoya - American Journal of Respiratory Cell and …, 2021 - atsjournals.org
ARDS is a clinical entity characterized by acutely worsening respiratory failure with bilateral
opacities, not fully explained by cardiac failure or fluid overload. Both direct (eg, pneumonia …
opacities, not fully explained by cardiac failure or fluid overload. Both direct (eg, pneumonia …
Loss of lung WWOX expression causes neutrophilic inflammation
S Singla, J Chen, S Sethuraman… - … of Physiology-Lung …, 2017 - journals.physiology.org
The tumor suppressor WW domain-containing oxidoreductase (WWOX) exhibits regulatory
interactions with an array of transcription factors and signaling molecules that are positioned …
interactions with an array of transcription factors and signaling molecules that are positioned …
WWOX gene restoration prevents lung cancer growth in vitro and in vivo
M Fabbri, D Iliopoulos, F Trapasso… - Proceedings of the …, 2005 - National Acad Sciences
The WWOX (WW domain containing oxidoreductase) gene at the common fragile site,
FRA16D, is altered in many types of cancer, including lung cancer. We have examined the …
FRA16D, is altered in many types of cancer, including lung cancer. We have examined the …
A functional copy number variation in the WWOX gene is associated with lung cancer risk in Chinese
L Yang, B Liu, B Huang, J Deng, H Li… - Human molecular …, 2013 - academic.oup.com
WW domain-containing oxidoreductase (WWOX) is a tumor suppressor that has been
reported to lose function due to genetic alterations in several cancers. WWOX maps to the …
reported to lose function due to genetic alterations in several cancers. WWOX maps to the …
The polymorphisms and haplotypes of WWOX gene are associated with the risk of lung cancer in southern and eastern Chinese populations
D Huang, F Qiu, L Yang, Y Li, M Cheng… - Molecular …, 2013 - Wiley Online Library
The WW domain‐containing oxidoreductase (WWOX) gene is an identified tumor
suppressor gene, of which several single nucleotide polymorphisms have been reported to …
suppressor gene, of which several single nucleotide polymorphisms have been reported to …
FOXO3 Activation Prevents Cellular Senescence in Emphysema Induced by Cigarette Smoke
H Jiang, Y Xu, Y Jiang, Y Li - COPD: Journal of Chronic Obstructive …, 2023 - Taylor & Francis
Because cigarette smoke can induce COPD/emphysema through accelerating senescence
with or without an incomplete repair system. However, the pathogenesis of COPD following …
with or without an incomplete repair system. However, the pathogenesis of COPD following …
FOXO3 deficiency leads to increased susceptibility to cigarette smoke-induced inflammation, airspace enlargement, and chronic obstructive pulmonary disease
J Hwang, S Rajendrasozhan, H Yao… - The Journal of …, 2011 - journals.aai.org
Forkhead box class O 3a (FOXO3) is a member of the FoxO transcription factor subfamily,
which regulates the expression of target genes not only through DNA binding as a …
which regulates the expression of target genes not only through DNA binding as a …
Comprehensive analysis of gene expression on GOLD-2 Versus GOLD-0 smokers reveals novel genes important in the pathogenesis of COPD
W Ning, J Lee, N Kaminski… - Proceedings of the …, 2006 - atsjournals.org
To better understand the molecular basis of chronic obstructive pulmonary disease (COPD),
we used serial analysis of gene expression (SAGE) and microarray analysis to compare the …
we used serial analysis of gene expression (SAGE) and microarray analysis to compare the …