The proteasome is a multicatalytic system involved in the degradation of polyubiquitinated
proteins. Thus, the proteasome is key to maintaining cell homeostasis. Stress and pro …

The immunoproteasome, a special class of the proteasome, is mainly expressed in cells of
haematopoietic origin. Additionally, during inflammation, the immunoproteasome is induced …

The proteasome is a multicatalytic enzyme expressed in all eukaryotic cells and responsible
for the degradation of polyubiquitinated proteins. Thereby, the proteasome regulates protein …

Polymyositis (PM) is a chronic autoimmune inflammatory myopathy resulting in muscle
weakness. The limited approved therapies and their poor efficacy contribute to its …

Numerous cellular processes are controlled by the proteasome, a multicatalytic protease in
the cytosol and nucleus of all eukaryotic cells, through regulated protein degradation. The …

Cells of hematopoietic origin express high levels of the immunoproteasome, a cytokine‐
inducible proteasome variant comprising the proteolytic subunits LMP2 (β1i), MECL‐1 (β2i) …

The immunoproteasome is a variant of the 26S proteasome in which the catalytically active
standard β-subunits (β1c, β2c and β5c) are replaced by low molecular mass polypeptide …

Treatment of cells with interferon-γ leads to the replacement of the constitutive catalytic
proteasome subunits β1, β2, and β5 by the inducible subunits LMP2 (β1i), MECL-1 (β2i) …

Background and Purpose Multicatalytic endopeptidase complex‐like‐1 (β2i), low molecular
mass polypeptide (LMP) 2 (β1i) and LMP7 (β5i) are the proteolytically active subunits of the …

Introduction Psoriasis is an autoimmune skin disease associated with multiple comorbidities.
The immunoproteasome is a special form of the proteasome expressed in cells of …