Uncaria rhynchophylla is a plant highly used in the traditional Chinese and Japanese
medicines. It has numerous health benefits, which are often attributed to its alkaloid …

Background Rhynchophylline (RHY) is an alkaloid component of Uncaria, which are plants
extensively used in traditional Asian medicines. Uncaria treatments increase sleep time and …

Rhynchophylline (RP) is a major tetracyclic oxindole alkaloid of Uncariae Ramulus et Uncus
which has been used to treat hypertension, seizures, pain and anxiety in the oriental …

Sleep, which is an essential part of human life, is modulated by neurotransmitter systems,
including gamma-aminobutyric acid (GABA) and dopamine signaling. However, the …

Patients with neurocognitive disorders often battle sleep disturbances. Kynurenic acid is a
tryptophan metabolite of the kynurenine pathway implicated in the pathology of these …

Sleep states comprise a constellation of physiologic and behavioral traits, and the
mechanisms by which sedative/hypnotic medications alter these traits remain unclear. Drugs …

Previous work showed that sleep is associated with increased brain protein synthesis and
that arrest of protein synthesis facilitates sleep. Arrest of protein synthesis is induced during …

L-stepholidine, an active ingredient of the Chinese herb Stephonia, is the first compound
known to have mixed dopamine D1 receptor agonist/D2 antagonist properties and to be a …

Serotonergic agonist psilocybin is a psychedelic with antidepressant potential. Sleep may
interact with psilocybin's antidepressant properties like other antidepressant drugs via …

AIM OF THE STUDY: Baicalin is an active compound originating from the root of Scutellaria
baicalensis Georgi, which has been used for anti-inflammation, anti-bacteria, anti …