Disturbances of the sleep-wake cycle are highly prevalent and diverse. The aetiology of
some sleep disorders, such as circadian rhythm sleep-wake disorders, is understood at the …

Emerging evidence indicates the role of amino acid metabolism in sleep regulation. Here we
demonstrate sleep-promoting effects of dietary threonine (SPET) in Drosophila. Dietary …

Aralia continentalis exhibits various biological activities; however, their sleep-promoting
effects have not been previously reported. In this study, we evaluated the hypnotic effects …

Insomnia is one of the most prevalent sleep disorders, which imparts tremendous societal
and economic impact. However, the present pharmacotherapy is greatly limited by adverse …

Hemerocallis citrina Baroni (HC) is an edible plant in Asia, and it has been traditionally used
for sleep-improvement. However, the bioactive components and mechanism of HC in sleep …

Levels of circulating gonadal hormones, including estrogens, affect both subjective and
objective measures of sleep quality. However, the mechanisms linking sex variables to …

Several studies have demonstrated the effectiveness of ketamine in rapidly alleviating
depression and suicidal ideation. Intense research efforts have been undertaken to expose …

Background As traditional Chinese medicine (TCM), nyctinastic herbs have been used in
treating insomnia in China since ancient times according to its similar circadian rhythm as …

Regulation of the sleep-waking cycle is complex, involving multiple neurological circuits and
diverse endogenous molecules. Interplay among assorted neuroanatomical and …

The global economic burdens of chronic degenerative diseases are a primary worldwide
concern for nutraceutical-pharmaceutical researchers. Insomnia is a potential risk factor of …