Neurotransmitter systems form the organizational backbone for this chapter. We briefly
summarize the central nervous system (CNS) excitatory and inhibitory neurotransmitters …

Context The sleep-promoting activity of Nelumbo nucifera Gaertn.(Nymphaeaceae)
alkaloids in leaves or seeds are well known. However, the sleep-promoting activity of the …

Our urge to sleep increases with time spent awake, until sleep becomes inescapable. The
sleep following sleep deprivation is longer and deeper, with an increased power of delta …

Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder with
limited therapeutic agents. Rhynchophylline (RIN), a tetracyclic oxindole alkaloid isolated …

Sleep is highly conserved across animal species. Both wake-and sleep-promoting neurons
are implicated in the regulation of wake–sleep transition at dusk in Drosophila. However …

On average, humans spend about 26 years of their life sleeping. Increased sleep duration
and quality has been linked to reduced disease risk; however, the cellular and molecular …

Sleep deprivation is associated with an elevated risk of various diseases and leads to a poor
quality of life and negative socioeconomic consequences. Sleep inducers such as drugs …

Objective To assess the biological effects of the six-herb mixture Anti-Insomia Formula (AIF)
extract using caffeine-induced insomnia Drosophila model and short-sleep mutants …

Sleep disturbances have been the hallmark of the recent coronavirus disease 2019
pandemic. Studies have shown that once sleep is disrupted, it can lead to psychological and …

Highlights•The mechanisms and sites of action for sleep-altering drugs are poorly
understood.•Conditional mouse mutants and optogenetics are identifying critical sleep …