Where do we look for the next breakthrough in sleep research?
The wakefulness-sleep cycle sets the pace of our life. Sleep research examines the
transition between wakefulness and sleep, its hormonal regulation, and its pathological …
transition between wakefulness and sleep, its hormonal regulation, and its pathological …
From Bench to Bedside and Back Again: translating circadian science to medicine
126 JOURNAL OF BIOLOGICAL RHYTHMS/April 2023 (a) preclinical (basic science using
animal models of disease) or epidemiological to identify targets of investigation,(b) clinical …
animal models of disease) or epidemiological to identify targets of investigation,(b) clinical …
Effects of paraxanthine and caffeine on sleep, locomotor activity, and body temperature in orexin/ataxin-3 transgenic narcoleptic mice
M Okuro, N Fujiki, N Kotorii, Y Ishimaru, P Sokoloff… - Sleep, 2010 - academic.oup.com
Abstract Study Objective: Caffeine, an adenosine A1 and A2a receptor antagonist, is a
widely consumed stimulant and also used for the treatment of hypersomnia; however, the …
widely consumed stimulant and also used for the treatment of hypersomnia; however, the …
Drug-induced insomnia and excessive sleepiness
A Van Gastel - Sleep medicine clinics, 2018 - sleep.theclinics.com
Sleep and waking function are closely connected in a 24-hour rhythm. The central nervous
system (CNS) structures involved in the promotion of the waking state include neurons …
system (CNS) structures involved in the promotion of the waking state include neurons …
Phosphorylation of Ca MKII in the rat dorsal raphe nucleus plays an important role in sleep–wake regulation
SY Cui, SJ Li, XY Cui, XQ Zhang, B Yu… - Journal of …, 2016 - Wiley Online Library
The Ca2+ modulation in the dorsal raphe nucleus (DRN) plays an important role in sleep–
wake regulation. Calmodulin‐dependent kinase II (Ca MKII) is an important signal …
wake regulation. Calmodulin‐dependent kinase II (Ca MKII) is an important signal …
Neurochemistry and pharmacology of sleep
P Torterolo, JM Monti, G Vanini - … , pharmacological, and clinical basis of the …, 2019 - Elsevier
In the last several decades, there has been a substantial increase in the knowledge of the
anatomy, electrophysiology, and neurochemistry of the neuronal networks that generate …
anatomy, electrophysiology, and neurochemistry of the neuronal networks that generate …
Drug-induced insomnia and excessive sleepiness
A Van Gastel - Sleep Medicine Clinics, 2022 - sleep.theclinics.com
Sleep and waking function are closely connected in a 24-hour rhythm. The central nervous
system (CNS) structures involved in the promotion of the waking state include neurons …
system (CNS) structures involved in the promotion of the waking state include neurons …
The pharmacology of human sleep, a work in progress?
C Idzikowski - Current Opinion in Pharmacology, 2014 - Elsevier
Highlights•“Sleep” and its control elements, both systemic and local, are highly
conserved.•Sleep and its functions are still not understood.•Pharmaceutical development …
conserved.•Sleep and its functions are still not understood.•Pharmaceutical development …
Psychopharmacology of sleep disorders
The concept of psychopharmacology has particular applicability to the study of sleep
because the states of sleep and wake are so intensely and complexly neurophysiologic in …
because the states of sleep and wake are so intensely and complexly neurophysiologic in …
ERK signaling pathway regulates sleep duration through activity-induced gene expression during wakefulness
C Mikhail, A Vaucher, S Jimenez, M Tafti - Science signaling, 2017 - science.org
Wakefulness is accompanied by experience-dependent synaptic plasticity and an increase
in activity-regulated gene transcription. Wake-induced genes are certainly markers of …
in activity-regulated gene transcription. Wake-induced genes are certainly markers of …