Objective: Impaired glymphatic waste clearance function during brain aging leads to the
accumulation of metabolic waste and neurotoxic proteins (eg, amyloid-β, tau) which …

Advanced age, accompanied by impaired glymphatic function, is a key risk factor for many
neurodegenerative diseases. To study age-related differences in the human glymphatic …

The glymphatic system is functional waste clearance path from the brain parenchyma
through dynamic exchange of cerebrospinal fluid (CSF) with interstitial fluid (ISF) …

Neurovascular pathology concurs with protein accumulation, as the brain vasculature is
important for waste clearance. Interstitial solutes, such as amyloid-β, were previously …

Sexual dimorphism is evident in brain structure, size, and function throughout multiple
species. Here, we tested whether cerebrospinal fluid entry into the glymphatic system, a …

The glymphatic system is a glial-dependent waste clearance pathway in the brain, in place
of lymphatic vessels, dedicated to drain away soluble waste proteins and metabolic …

The glymphatic system is a newly discovered waste drainage pathway in the brain; it plays
an important role in many neurological diseases. Ongoing research utilizing various …

ABSTRACT BACKGROUND AND PURPOSE Recently, there has been growing interest in
the glymphatic system (the functional waste clearance pathway for the central nervous …

The glymphatics system describes a CSF-mediated clearance pathway for the removal of
potentially harmful molecules, such as amyloid beta, from the brain. As such, its components …

Accumulation in the brain of metabolic waste products such as amyloid-β and
hyperphosporylated tau (tau) is a hallmark of dementia (eg, Alzheimer's disease). One …