Delayed clearance of cerebrospinal fluid tracer from entorhinal cortex in idiopathic normal pressure hydrocephalus: a glymphatic magnetic resonance imaging study

PK Eide, G Ringstad - Journal of Cerebral Blood Flow & …, 2019 - journals.sagepub.com
The glymphatic system plays a key role for clearance of waste solutes from the rodent brain.
We recently found evidence of glymphatic circulation in the human brain when using …

High-resolution 3D demonstration of regional heterogeneity in the glymphatic system

XZ He, X Li, ZH Li, JC Meng, RT Mao… - Journal of Cerebral …, 2022 - journals.sagepub.com
Accumulating evidence indicates that the glymphatic system has a critical role in maintaining
brain homeostasis. However, the detailed anatomy of the glymphatic pathway is not well …

MRI investigation of glymphatic responses to Gd‐DTPA infusion rates

G Ding, M Chopp, L Li, L Zhang… - Journal of …, 2018 - Wiley Online Library
The glymphatic system is a newly identified waste clearance pathway in brain discovered
and investigated predominately using in vivo two‐photon confocal microscopy. Magnetic …

[HTML][HTML] MRI of whole rat brain perivascular network reveals role for ventricles in brain waste clearance

KN Magdoom, A Brown, J Rey, TH Mareci, MA King… - Scientific reports, 2019 - nature.com
Investigating the mechanisms by which metabolic wastes are cleared from nervous tissue is
important for understanding natural function and the pathophysiology of several …

Impairment of paravascular clearance pathways in the aging brain

BT Kress, JJ Iliff, M Xia, M Wang, HS Wei… - Annals of …, 2014 - Wiley Online Library
Objective In the brain, protein waste removal is partly performed by paravascular pathways
that facilitate convective exchange of water and soluble contents between cerebrospinal …

[HTML][HTML] Research on the Glial–Lymphatic System and Its Relationship With Alzheimer's Disease

D Ding, X Wang, Q Li, L Li, J Wu - Frontiers in Neuroscience, 2021 - frontiersin.org
Metabolic waste clearance is essential to maintain body homeostasis, in which the lymphatic
system plays a vital role. Conversely, in recent years, studies have identified the glial …

[HTML][HTML] Impaired peri-olfactory cerebrospinal fluid clearance is associated with ageing, cognitive decline and dyssomnia

Y Zhou, W Ran, Z Luo, J Wang, M Fang, K Wei, J Sun… - …, 2022 - thelancet.com
Background Animal experiments have demonstrated the dependency of cerebrospinal fluid
clearance function on age and sleep, which partially underlay the cognitive decline in the …

Quantitative and qualitative assessment of glymphatic flux using Evans blue albumin

MS Wolf, Y Chen, DW Simon, H Alexander… - Journal of neuroscience …, 2019 - Elsevier
Background The glymphatic system is a proposed pathway for clearance of proteins and
macromolecules from brain, and disrupted glymphatic flux is implicated in neurological …

Glymphatic system dysfunction in middle-aged and elderly chronic insomnia patients with cognitive impairment evidenced by diffusion tensor imaging along the …

Y Jin, W Zhang, M Yu, J Li, Y Du, W Wang, G Chen… - Sleep Medicine, 2024 - Elsevier
Background Chronic insomnia impairs the glymphatic system and may lead to cognitive
impairment and dementia in elderly population. The diffusion tensor image analysis along …

[HTML][HTML] Acute systemic LPS-exposure impairs perivascular CSF distribution in mice

O Manouchehrian, M Ramos, S Bachiller… - Journal of …, 2021 - Springer
Background The exchange of cerebrospinal (CSF) and interstitial fluid is believed to be vital
for waste clearance in the brain. The sleep-dependent glymphatic system, which is …