Does the sympathetic nervous system adapt to chronic altitude exposure?

M Sander - Hypoxia: Translation in Progress, 2016 - Springer
During continued exposure to hypobaric hypoxia in acclimatizing lowlanders increasing
norepinephrine levels indirectly indicate sympathoexcitation, and in a few subjects serial …

Sustained sympathetic activity in altitude acclimatizing lowlanders and high‐altitude natives

C Lundby, J Calbet, G Van Hall… - … journal of medicine & …, 2018 - Wiley Online Library
Combined results from different independent studies suggest that acclimatization to high
altitude induces a slowly developing sympathetic activation, even at levels of hypoxia that …

Carotid chemoreceptor control of muscle sympathetic nerve activity in hypobaric hypoxia

JP Fisher, D Flück, MP Hilty… - Experimental physiology, 2018 - Wiley Online Library
New Findings What is the central question of this study? High‐altitude hypoxia increases
muscle sympathetic nerve activity (MSNA), but whether intravenous infusion of dopamine, to …

Sympathetic neural overactivity in healthy humans after prolonged exposure to hypobaric hypoxia

J Hansen, M Sander - The Journal of physiology, 2003 - Wiley Online Library
Acute exposure to hypoxia causes chemoreflex activation of the sympathetic nervous
system. During acclimatization to high altitude hypoxia, arterial oxygen content recovers, but …

Human autonomic activity and its response to acute oxygen supplement after high altitude acclimatization

X Bao, BP Kennedy, SR Hopkins, HJ Bogaard… - Autonomic …, 2002 - Elsevier
It is well established that after acclimatization at high altitude, many sympathetic pathways
are hyperactive yet heart rate (HR) remains unchanged. In this study, we attempted to …

Reduced autonomic activity during stepwise exposure to high altitude

K Sevre, B Bendz, E Hankø, AR Nakstad… - Acta Physiologica …, 2001 - Wiley Online Library
Several studies have shown increased sympathetic activity during acute exposure to
hypobaric hypoxia. In a recent field study we found reduced plasma catecholamines during …

Acclimatization to high altitude increase muscle sympathetic activity both at rest and during exercise

RS Mazzeo, GA Brooks, GE Butterfield… - American Journal …, 1995 - journals.physiology.org
This investigation examined the relationship between alterations in plasma norepinephrine
associated with 21 days of high-altitude exposure and muscle sympathetic activity both at …

Mechanisms underpinning sympathoexcitation in hypoxia

LL Simpson, M Stembridge… - The Journal of …, 2024 - Wiley Online Library
Sympathoexcitation is a hallmark of hypoxic exposure, occurring acutely, as well as
persisting in acclimatised lowland populations and with generational exposure in highland …

Influence of recent altitude exposure on sea level sympathetic neural & hemodynamic responses to orthostasis

KM Mitchell, KE Bradbury, AM Posch… - Autonomic …, 2018 - Elsevier
Although it has been shown that muscle sympathetic nerve activity increases during high
altitude exposure, mechanisms of sympathoexcitation and blood pressure control after …

Sympathetic response during 21 days at high altitude (4,300 m) as determined by urinary and arterial catecholamines

RS Mazzeo, EE Wolfel, GE Butterfield, JT Reeves - Metabolism, 1994 - Elsevier
The sympathoadrenal system plays a major role in adjustments to both short-and long-term
high-altitude exposure. Thus, this study investigated catecholamine responses in blood …