In France, the legal routes used to administer midazolam to a patient are intravenously and
intramuscularly. For anaesthetists, these routes are not well adapted to paediatric use; they …

Background Midazolam is used widely as a sedative to facilitate mechanical ventilation. This
prospective study investigated the population pharmacokinetics of midazolam in very …

Background: In children, a large variability in pharmacokinetics of midazolam, a cytochrome
P450 3A4/5 (CYP3A4/5) enzyme substrate, has been described, which cannot be explained …

Twelve children 1-5 y old were randomly assigned to receive midazolam 0.2 mg. kg-1 either
by the intravenous (IV) or intranasal (IN) routes. After IN administration the rapid onset of …

Aim In view of the increasing prevalence of obesity in adolescents, the aim of this study was
to determine the pharmacokinetics of the CYP3A substrate midazolam and its metabolites in …

Aims Inflammation and organ failure have been reported to have an impact on cytochrome
P450 (CYP) 3A‐mediated clearance of midazolam in critically ill children. Our aim was to …

Midazolam 0.3 mg kg− 1 was given as a single dose to three groups of children undergoing
cardiac surgery to determine its pharmacokinetic profile in this situation. The first group …

Objectives To determine the extent of inter-individual variation in clearance of midazolam in
children and establish which factors are responsible for this variation. Methods A systematic …

The aim of the study was to study a possible pharmacokinetic-pharmacodynamic (PK-PD)
relationship for midazolam in pediatric intensive care patients and to determine how …

Purpose Changes in drug absorption and first-pass metabolism have been reported
throughout the pediatric age range. Our aim is to characterize both intestinal and hepatic …