Abstract Background Fractalkine (CX3CL1; FKN) is a chemokine expressed by neurons that
mediates communication between neurons and microglia. By regulating microglial activity …

Fractalkine (FKN, CX3CL1) is a transmembrane chemokine expressed by neurons in the
central nervous system (CNS). CX3CL1 signals through its unique receptor, CX3CR1, that is …

The chemokine fractalkine (FKN, CX3CL1), a member of the CX3C subfamily, contributes to
neuron–glia interaction and the regulation of microglial cell activation. Fractalkine is …

Multiple sclerosis (MS), an inflammatory demyelinating disease of the central nervous
system (CNS) is the leading cause of non-traumatic neurological disability in young adults …

Fractalkine (CX3CL1) is an intriguing chemokine that plays a central role in the nervous
system. The expression of CX3CL1 on neurons and of its receptor CX3CR1 on microglia …

Leukocyte migration and activation play an important role in immune surveillance and the
pathogenesis of a variety of neurodegenerative disorders, including human …

Neuroinflammation was initially thought of as a consequence of neurodegenerative disease
pathology, but more recently it is becoming clear that it plays a significant role in the …

CX3CR1 is a G protein‐coupled receptor that is expressed exclusively by microglia within
the brain parenchyma. The only known physiological CX3CR1 ligand is the chemokine …

Abstract Background Fractalkine (CX 3 CL1) and its receptor (CX 3 CR1) play an important
role in regulating microglial function. We have previously shown that Cx 3 cr1 deficiency …

An essential aspect of normal brain function is the bidirectional interaction and
communication between neurons and neighbouring glial cells. To this end, the brain has …