The inability to quantify cerebral blood flow and changes in macrocirculation cross-sectional
area in all brain regions impedes robust insight into hypoxic cerebral blood flow control. We …

Conflicting results reported on the effects of hyperoxia on cerebral hemodynamics have
been attributed mainly to methodical and species differences. In the present study contrast …

The brain is a vital organ that relies on a constant and adequate supply of blood to match
oxygen and glucose delivery with the local metabolic demands of active neurones. It is well …

New Findings• What is the central question of this study? Does hypoxia enhance blood flow
to all parts of the brain uniformly?• What is the main finding and its importance? During …

We examined 1) whether global cerebral blood flow (CBF) would increase across a 6-h bout
of normobaric poikilocapnic hypoxia and be mediated by a larger increase in blood flow in …

Key points Cognitive performance is impaired by hypoxia despite global cerebral oxygen
delivery and metabolism being maintained. Using arterial spin labelled (ASL) magnetic …

Background and Purpose—To determine how cerebral blood flow (CBF), total and
microvascular cerebral blood volume (CBV), and blood oxygenation level–dependent …

The postulation that hypoxia increases local cerebral blood flow (lCBF) mainly by perfusing
more capillaries (the capillary recruitment hypothesis) was tested in awake adult male …

Aim The role of reactive oxygen species (ROS) in human cerebral blood flow (CBF) during
hypoxia is largely unknown. Additionally, it is unknown whether ROS interact with …

What is the organization of cerebral microvascular oxygenation and morphology that allows
adequate tissue oxygenation at different activity levels? We address this question in the …