Background: Thrombophilia is a hypercoagulable state characterized by increased venous
thrombosis. The most common cause of heritable thrombophilia is Factor V Leiden …

Objective: To determine the diagnostic accuracy of clotting based APCR assay in
determining Factor V Leiden mutation with PCR as gold standard and to establish the …

Materials and Methods: Whole venous blood samples were collected from 400 patients with
VTE and 200 healthy controls, all of whom were of Arab ethnicity living in Kuwait. The …

A new prothrombin-based activated protein C resistance (APC-R) test is described. In this
method, the patient sample is prediluted in a plasma depleted of factor V (FV). A reagent …

Sažetak The goal of every coagulation laboratory is to find a reliable screening test for the
detection of activated protein C resistance (APCR) that will be suitable for routine work and …

Abstract Context.—Factor V Leiden (FVL) is the most common heritable cause of venous
thrombosis. It is caused by a single nucleotide substitution resulting in an R506Q missense …

The aim of this study was to evaluate critically the recently modified activated-partial-
thromboplastin-time (APTT)-based activated protein C (APC)-resistance tests, which are …

The most common commercially available test measuring activated protein C (APC)
resistance relies on the the anticoagulant response to added APC in an activated partial …

The factor V Leiden (FVL) polymorphism is known as the most common inherited risk factor
for venous thrombosis. In turn, FVL is the leading cause of an activated protein C resistance …

Activated protein C resistance (APCR) is a coagulation abnormality often linked to FV
Leiden mutation, a single nucleotide G1691A substitution resulting in arginine 506→ …