Purpose. The aim of this work was to synthesize new surface-modified nanoparticles using a
radical emulsion polymerization of an alkyl cyanoacrylate. Methods. Isobutyl cyanoacrylate …

The composition of lyophilised PBCA nanoparticles was characterised by three different
analytical methods, ie, GC, spectrophotometry and fluorimetry. The quantification of PBCA …

Poly (alkyl cyanoacrylates) are biodegradable and biocompatible polymers. Ethyl, n‐butyl
and octyl cyanoacrylate have been approved in the last decades by the US Food and Drug …

Doxorubicin (Dox) is widely used for the combined chemotherapy of solid tumors. However,
the use of these drug associations in lung cancer has low antitumor efficacy. To improve its …

A new kind of polyelectrolyte complex (PEC) based on cationic chitosan (CS) and anionic
poly (2-acry1amido-2-methylpropanesulfonic acid)(PAMPS) was prepared using a polymer …

Background Combination therapy employing multiple drugs has been shown to enhance the
efficacy of cancer treatment. Chlorambucil (Chl) and 6-mercaptopurine (6MP) are the first …

A considerable amount of energy has been spent in creating new colloidal drug delivery
systems that are acceptable for general systemic use. Among these new systems …

Carboplatin is a platinum based drug used in the treatment of several malignancies. Due to
poor cellular uptake, generally, a larger dose of drug is administered to achieve therapeutic …

Cancer is one of the most important issues in modern medicine and the most common cause
of death after cardiovascular diseases in many countries. Brain cancer is one of the most …

Objective: The present investigation was aimed to overcome the limitations and to enhance
the incorporation of the hydrophobic drug into polymeric nanoparticles and characterize the …