Metabolic disease, including obesity and type 2 diabetes, constitutes a major emerging
health crisis in Western nations. Although the symptoms and clinical pathology and …

Sphingolipids play an important role in the development of diabetes, both type 1 and type 2
diabetes, as well as in the development of both micro-and macro-vascular complications …

Sphingolipids are a family of lipid molecules produced through different pathways in
mammals. Sphingolipids are structural components of membranes, but in response to …

Despite considerable attention to the question of how sphingolipids induce metabolic
disease, there exist enormous gaps in knowledge. Further elucidation of these molecular …

Obesity and dyslipidemia are risk factors for metabolic disorders including diabetes and
cardiovascular disease. Sphingolipids such as ceramide and glucosylceramides, while …

Sphingolipids, ubiquitously produced in all vertebrate cells, are biologically active lipids that
are the structural components of cell membranes. They also function as intracellular and …

Sphingolipids are an important class of structural and signaling molecules within the cell. As
sphingolipids have been implicated in the development and pathogenesis of insulin …

The contribution of aberrant production of bioactive lipids to pathophysiological changes
associated with obesity has risen to the forefront of lipid research. Increased diacylglycerol …

The sphingolipid field has made significant strides over the past 10 years: from identifying
metabolites of the sphingomyelin pathway as second messengers to discerning the …

Alterations in lipid metabolism may contribute to diabetic complications. Sphingolipids are
essential components of cell membranes and have essential roles in homeostasis and in the …