An alternative method for the analysis of melanin production in Cryptococcus neoformans sensu lato and Cryptococcus gattii sensu lato

RSN Brilhante, JDA España, LP de Alencar… - Mycoses, 2017 - Wiley Online Library
Melanin is an important virulence factor for several microorganisms, including Cryptococcus
neoformans sensu lato and Cryptococcus gattii sensu lato, thus, the assessment of melanin …

[HTML][HTML] Differential antifungal activity of human and cryptococcal melanins with structural discrepancies

N Correa, C Covarrubias, PI Rodas… - Frontiers in …, 2017 - frontiersin.org
Melanin is a pigment found in all biological kingdoms, and plays a key role in protection
against ultraviolet radiation, oxidizing agents, and ionizing radiation damage. Melanin exerts …

[HTML][HTML] Genetic Factors and Genotype-Environment Interactions Contribute to Variation in Melanin Production in the Fungal Pathogen Cryptococcus neoformans

H Samarasinghe, D Aceituno-Caicedo, M Cogliati… - Scientific reports, 2018 - nature.com
Cryptococcosis is a common opportunistic fungal infection that often disseminates into the
central nervous system, leading to meningitis. Production of melanin pigments during …

[HTML][HTML] Reciprocal modulation of ammonia and melanin production has implications for cryptococcal virulence

RP Baker, A Casadevall - Nature communications, 2023 - nature.com
The fungus Cryptococcus neoformans is the causative agent of cryptococcosis, a disease
that is uniformly lethal unless treated with antifungal drugs, yet current regimens are …

Reduced virulence of melanized Cryptococcus neoformans in Galleria mellonella

HC Eisenman, R Duong, H Chan, R Tsue… - Virulence, 2014 - Taylor & Francis
Fungal melanins are important in the virulence of many pathogenic fungi. In this study, we
examined the role of melanin in the interaction between Cryptococcus neoformans and the …

The discovery of melanin production in Cryptococcus neoformans and its impact on diagnosis and the study of virulence

I Polacheck - Zentralblatt für Bakteriologie, 1991 - Elsevier
The Discovery of Melanin Production in Cryptococcus neoformans and its Impact on Diagnosis
and the Study of Virulence Page 1 Zbl. Bakt. 276, 120-123 (1991) © Gustav Fischer Verlag …

[HTML][HTML] Solid-state NMR reveals the carbon-based molecular architecture of Cryptococcus neoformans fungal eumelanins in the cell wall

S Chatterjee, R Prados-Rosales, B Itin… - Journal of Biological …, 2015 - ASBMB
Melanin pigments protect against both ionizing radiation and free radicals and have
potential soil remediation capabilities. Eumelanins produced by pathogenic Cryptococcus …

Establishment of protective immunity against cerebral cryptococcosis by means of an avirulent, non melanogenic Cryptococcus neoformans strain

R Barluzzi, A Brozzetti, G Mariucci, M Tantucci… - Journal of …, 2000 - Elsevier
The opportunistic fungal pathogen, Cryptococcus neoformans, shows a marked predilection
for the central nervous system (CNS). This can be partially explained by its ability to …

[HTML][HTML] Faster Cryptococcus Melanization Increases Virulence in Experimental and Human Cryptococcosis

HR de Sousa, GP de Oliveira Jr, SO Frazão… - Journal of Fungi, 2022 - mdpi.com
Cryptococcus spp. are human pathogens that cause 181,000 deaths per year. In this work,
we systematically investigated the virulence attributes of Cryptococcus spp. clinical isolates …

Melanin-deficient mutants of Cryptococcus neoformans

H Torres-Guererro, JC Edman - Journal of medical and veterinary …, 1994 - Taylor & Francis
Cryptococcus neoformans is a significant fungal pathogen in immunocompromised patients.
The ability of C. neoformans to produce melanin has been correlated with virulence. The …