Signalling pathways in the pathogenesis of Cryptococcus

L Kozubowski, SC Lee, J Heitman - Cellular microbiology, 2009 - Wiley Online Library
Efficient communication with the environment is critical for all living organisms. Fungi utilize
complex signalling systems to sense their environments and control proliferation …

A High-Throughput Screening Assay for Fungicidal Compounds against Cryptococcus neoformans

JLA Rabjohns, YD Park, J Dehdashti… - Journal of …, 2014 - journals.sagepub.com
Cryptococcus neoformans is a pathogenic fungus that causes meningitis worldwide,
particularly in human immunodeficiency virus (HIV)–infected individuals. Although …

Detection of Melanin-Like Pigments in the Dimorphic Fungal Pathogen Paracoccidioides brasiliensis In Vitro and during Infection

BL Gómez, JD Nosanchuk, S Dı́ez… - Infection and …, 2001 - Am Soc Microbiol
Melanins are implicated in the pathogenesis of several human diseases, including some
microbial infections. In this study, we analyzed whether the conidia and the yeasts of the …

The melanization road more traveled by: Precursor substrate effects on melanin synthesis in cell-free and fungal cell systems

S Chatterjee, R Prados-Rosales, S Tan… - Journal of Biological …, 2018 - ASBMB
Natural brown–black eumelanin pigments confer structural coloration in animals and
potently block ionizing radiation and antifungal drugs. These functions also make them …

Histoplasma capsulatum Synthesizes Melanin-Like Pigments In Vitro and during Mammalian Infection

JD Nosanchuk, BL Gómez, S Youngchim… - Infection and …, 2002 - Am Soc Microbiol
Melanin is made by several important pathogenic fungi and has been implicated in the
pathogenesis of a number of fungal infections. This study investigated whether the thermally …

Cellular charge of Cryptococcus neoformans: contributions from the capsular polysaccharide, melanin, and monoclonal antibody binding

JD Nosanchuk, A Casadevall - Infection and immunity, 1997 - Am Soc Microbiol
Cryptococcus neoformans is a human pathogenic fungus which is unusual in two respects: it
has a polysaccharide capsule similar to that found in encapsulated bacteria and it can …

Phenoloxidase activity and virulence in isogenic strains of Cryptococcus neoformans

JC Rhodes, I Polacheck, KJ Kwon-Chung - Infection and Immunity, 1982 - Am Soc Microbiol
A naturally occurring Mel-variant of Cryptococcus neoformans was isolated from the wild
type. The effect of phenoloxidase activity on virulence was analyzed on genetically …

Activation of the alternative complement pathway by fungal melanins

AL Rosas, RS MacGill, JD Nosanchuk… - Clinical and Vaccine …, 2002 - Am Soc Microbiol
Melanins are complex biological pigments formed by the oxidative polymerization of
phenolic and/or indolic compounds. These pigments have been implicated in the …

Biosynthesis and Functions of Melanin inSporothrix schenckii

R Romero-Martinez, M Wheeler… - Infection and …, 2000 - Am Soc Microbiol
Sporothrix schenckii is a human pathogen that causes sporotrichosis, an important
cutaneous mycosis with a worldwide distribution. It produces dark-brown conidia, which …

Coccidioides posadasii produces melanin in vitro and during infection

JD Nosanchuk, JJ Yu, CY Hung, A Casadevall… - Fungal Genetics and …, 2007 - Elsevier
Using techniques developed to study melanization in other fungi, we demonstrate that
Coccidioides posadasii arthroconidia, spherules, and endospores produce melanin or …