Chemoradiation in elderly patients with glioblastoma from the multi-institutional GBM-molRPA cohort: is short-course radiotherapy enough or is it a matter of selection?

CW Wee, IH Kim, CK Park, N Kim, CO Suh… - Journal of Neuro …, 2020 - Springer
Background The optimal radiotherapy regimen in elderly patients with glioblastoma treated
by chemoradiation needs to be addressed. We provide the results of a comparison between …

Elderly patients aged 65–75 years with glioblastoma multiforme may benefit from long course radiation therapy with temozolomide

C Gzell, H Wheeler, L Guo, M Kastelan… - Journal of neuro-oncology, 2014 - Springer
To determine the outcome of elderly patients with glioblastoma managed with
hypofractionated [40 Gray (Gy)] or long-course (60 Gy) radiation therapy (RT). Patients …

Standard dose and dose-escalated radiation therapy are associated with favorable survival in select elderly patients with newly diagnosed glioblastoma

WC Jackson, CI Tsien, L Junck, D Leung… - Journal of neuro …, 2018 - Springer
We hypothesized elderly patients with good Karnofsky Performance Status (KPS) treated
with standard dose or dose-escalated radiation therapy (SDRT/DERT) and concurrent …

Radiotherapy with or without temozolomide in elderly patients aged≥ 70 years with glioblastoma

E Metcalfe, O Karaoglanoglu, E Akyazici - Contemporary Oncology …, 2016 - termedia.pl
Conclusions: RT±TMZ seems to be a well-tolerated treatment in patients≥ 70 years with
GBM. Even though no superiority was found between conventional or hypofractionated RT …

Standard (60 Gy) or short-course (40 Gy) irradiation plus concomitant and adjuvant temozolomide for elderly patients with glioblastoma: a propensity-matched …

G Minniti, C Scaringi, G Lanzetta, I Terrenato… - International Journal of …, 2015 - Elsevier
Purpose To evaluate 2 specific radiation schedules, each combined with temozolomide
(TMZ), assessing their efficacy and safety in patients aged≥ 65 years with newly diagnosed …

Hypofractionated radiotherapy followed by adjuvant chemotherapy with temozolomide in elderly patients with glioblastoma

G Minniti, V De Sanctis, R Muni, D Rasio… - Journal of neuro …, 2009 - Springer
Objectives The optimal treatment for elderly patients (age> 70 years) with glioblastoma
(GBM) remains controversial. We conducted a prospective trial in 43 consecutive elderly …

Can elderly patients with newly diagnosed glioblastoma be enrolled in radiochemotherapy trials?

A Fiorentino, M Balducci, P De Bonis… - American Journal of …, 2015 - journals.lww.com
Objectives: Age is an unfavorable prognostic factor in glioblastoma multiforme (GBM). To
assess the possibility and the advantage of radiotherapy (RT) plus concomitant/sequential …

Radiotherapy with concurrent or sequential temozolomide in elderly patients with glioblastoma multiforme

SA Hashem, A Salem, A Al‐Rashdan… - Journal of Medical …, 2012 - Wiley Online Library
Objective: The objective of this article was to evaluate therapeutic outcomes of elderly
patients with glioblastoma multiforme (GBM) treated by surgery followed by combined …

Radiotherapy plus temozolomide in elderly patients with glioblastoma: a “real-life” report

J Biau, E Chautard, E De Schlichting, G Dupic… - Radiation …, 2017 - Springer
Background The optimization of the management for elderly glioblastoma patients is crucial
given the demographics of aging in many countries. We report the outcomes for a “real-life” …

Toxicity from chemoradiotherapy in older patients with glioblastoma multiforme

AE Sijben, JB McIntyre, GB Roldán, JC Easaw… - Journal of neuro …, 2008 - Springer
Introduction Elderly patients have glioblastomas (GBM) that are aggressive and poorly
responsive to treatment. They are also prone to the side effects of treatment of GBM …